Left ventricular mechanical synchrony and global systolic function in pediatric patients late after ventricular septal defect patch closure: a three-dimensional echocardiographic study

Congenital Heart Disease
Surendranath Reddy Veeram ReddyMark V Zilberman

Abstract

Patients with large ventricular septal defects (VSDs) undergo surgical patch closure during infancy. The long-term effects of the presence of akinetic patch in the ventricular septum and postoperative right bundle branch block (RBBB) on the left ventricular (LV) mechanical synchrony and global systolic function have not been studied. The objective of this study was to evaluate the long-term effects of an akinetic VSD patch and RBBB on the LV mechanical synchrony and global systolic function in pediatric patients more than 5 years after surgery. Eighteen asymptomatic VSD repair and 18 normal control patients were evaluated by an electrocardiogram and three-dimensional echocardiography. Left ventricular end-diastolic volumes (LVEDVs) and volumetric ejection fraction (EF) were calculated. Left ventricular intraventricular synchrony was assessed by the 16-segment volumetric dyssynchrony index. Eight of 18 (44%) patients in the VSD repair group had RBBB. The LVEDV and volumetric EF were similar in the VSD repair and control groups. The LV dyssynchrony index was not significantly different between the VSD repair and control groups (2.46 +/- 1.77% vs. 1.75 +/- 1.08%, P = .16). The VSD repair group was then divided into two subgroups: ...Continue Reading

References

Oct 1, 1964·The American Journal of Cardiology·M LEVM H WEINBERG
Sep 29, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T Alexander QuinnHenry M Spotnitz
Nov 3, 2004·Journal of the American College of Cardiology·Jeroen J BaxMartin J Schalij
Dec 13, 2006·Journal of the American College of Cardiology·Gabe B BleekerJeroen J Bax
Oct 2, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·G Hamilton BakerGirish S Shirali

❮ Previous
Next ❯

Citations

Jul 14, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shuping Ge
Jul 1, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Anitha ParthibanShelby Kutty
Oct 31, 2017·European Journal of Clinical Investigation·Sit-Yee KwokYiu-Fai Cheung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved