Left ventricular myocardial deformation abnormalities in seizure-free children with epilepsy

Seizure : the Journal of the British Epilepsy Association
Serkan Fazlı ÇelikYasemin Altuner Torun

Abstract

Although there is a higher risk of structural cardiac disease in people with epilepsy, there is no detailed advanced analysis of cardiac functions in patients with epilepsy. This study aimed to determine early echocardiographic findings of Left Ventricular (LV) dysfunction using cardiac strain technique in seizure-free children with epilepsy. The study investigated 60 children with epilepsy who had no seizures in the preceding 6 months, without any known cardiovascular disease and treated with one antiepileptic drug and 60 healthy subjects who underwent clinical evaluation including electrocardiography (ECG), standard echocardiography, tissue Doppler imaging (TDI) and two-dimensional Speckle Tracking Echocardiography (2DSTE). Despite the normal M-mode values, global longitudinal strain of the epilepsy of the control group was as follows: -16.86 ± 3.71, -18.95 ± 3.75, respectively (p = 0.001); global strain rates were determined as follows: -0.99 ± 0.23, -1.14 ± 0.31, respectively (p = 0003). The patients also had increased A-wave velocity, and decreased E/A ratio (p < 0.01). TDI results showed diastolic dysfunction as mirrored by significantly increased isovolemic relaxation time (IVRT), Early mitral inflow (E)/ Early diastolic...Continue Reading

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Citations

Oct 15, 2020·Epilepsia·John M SchreiberWilliam D Gaillard
Jan 11, 2021·Epilepsy & Behavior : E&B·Fangzhao YinGuojun Zhang
May 29, 2021·Annals of Clinical and Translational Neurology·Giorgio CostagliolaPasquale Striano
Aug 27, 2021·Frontiers in Pediatrics·John AllenEleanor J Molloy

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