Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure

American Journal of Physiology. Heart and Circulatory Physiology
Pál PacherCsaba Szabó

Abstract

Aging is associated with profound changes in the structure and function of the heart. A fundamental understanding of these processes, using relevant animal models, is required for effective prevention and treatment of cardiovascular disease in the elderly. Here, we studied cardiac performance in 4- to 5-mo-old (young) and 24- to 26-mo-old (old) Fischer 344 male rats using the Millar pressure-volume (P-V) conductance catheter system. We evaluated systolic and diastolic function in vivo at different preloads, including preload recruitable stroke work (PRSW), maximal slope of the systolic pressure increment (+dP/dt), and its relation to end-diastolic volume (+dP/dt-EDV) as well as the time constant of left ventricular pressure decay, as an index of relaxation. The slope of the end-diastolic P-V relation (EDPVR), an index of left ventricular stiffness, was also calculated. Aging was associated with decrease in left ventricular systolic pressure, +dP/dt, maximal slope of the diastolic pressure decrement, +dP/dt-EDV, PRSW, ejection fraction, stroke volume, cardiac and stroke work indexes, and efficiency. In contrast, total peripheral resistance, left ventricular end-diastolic volume, left ventricular end-diastolic pressure, and EDPVR...Continue Reading

References

Jan 1, 1978·Acta Anaesthesiologica Scandinavica·J H Christensen, F Andreasen
Jun 1, 1992·The American Journal of Physiology·J M CapassoP Anversa
Oct 1, 1990·The American Journal of Physiology·J M CapassoP Anversa
May 1, 1989·The American Journal of Physiology·P AnversaE H Sonnenblick
Aug 1, 1989·The American Journal of Physiology·M O BoluytT P White
Apr 1, 1993·Physiological Reviews·E G Lakatta
Sep 1, 1996·The American Journal of Physiology·J KajsturaP Anversa
May 12, 1998·The American Journal of Physiology·D GeorgakopoulosD A Kass
Jan 22, 2000·Science·A M MurphyE Marbán
Jun 8, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M O BoluytT P White
Sep 28, 2000·Journal of Applied Physiology·D P ThomasR J McCormick
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M D FeldmanG L Freeman
Jul 17, 2001·The Journal of Physiology·D Georgakopoulos, D Kass
Mar 22, 2002·British Journal of Pharmacology·Pál PacherCsaba Szabó
Aug 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Matthias NahrendorfWolfgang R Bauer
Jul 1, 1961·Anesthesiology·J W ECKSTEINJ M McCAMMOND
Feb 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Thomas S MaxeyAllan Doctor

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Citations

Apr 16, 2011·Pflügers Archiv : European journal of physiology·Christian BollensdorffPeter Kohl
Feb 1, 2011·Cardiovascular Toxicology·Alex P CarllAimen K Farraj
Dec 12, 2007·Rejuvenation Research·Nicola FerraraAmelia Filippelli
May 23, 2012·Tissue Engineering. Part a·Ling QianPhilip Wong
Feb 16, 2010·Cardiovascular Research·Mi-Young KimYi-Sook Jung
Sep 8, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eunhee Chung, Gary M Diffee
Apr 23, 2009·Critical Care Medicine·Basilia ZingarelliAlex B Lentsch
Sep 6, 2012·Molecular and Cellular Biology·Hadi KhalilChristian Widmann
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Samuel C LieberDorothy E Vatner
Apr 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sándor BátkaiPál Pacher
Jul 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·ByungSu YooHoward A Rockman
Jun 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sándor BátkaiGeorge Kunos
Nov 23, 2007·American Journal of Physiology. Renal Physiology·David J KennedyJoseph I Shapiro
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Jan 11, 2013·BMC Systems Biology·Tianyi YangYu-Fang Jin
May 28, 2014·Microvascular Research·Alessio RungatscherGiuseppe Faggian
Jun 24, 2014·Heart, Lung & Circulation·Abraham E WeiMark A Lovich
Oct 10, 2013·Stem Cells Translational Medicine·Amanda J LeblancStuart K Williams
Aug 8, 2012·The American Journal of Emergency Medicine·Surapong ChatpunPedro Cabrales
May 10, 2012·Experimental Gerontology·Jochen SteppanDan E Berkowitz
Aug 7, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Winston S N ShimPhilip Wong
Mar 24, 2010·Differentiation; Research in Biological Diversity·Genevieve TanPhilip Wong
May 12, 2009·Ultrasound in Medicine & Biology·Wei Zhang, Sándor J Kovács
Nov 15, 2008·Journal of Molecular and Cellular Cardiology·Mihail I MitovKenneth S Campbell
Apr 26, 2005·Experimental Physiology·Matthias SiepeHendrik T Tevaearai
May 14, 2009·Molecular Nutrition & Food Research·Estatira SepehrG Sarwar Gilani
Jan 1, 2010·Journal of Cellular and Molecular Medicine·Mohsin KhanSheikh Riazuddin
May 24, 2006·Life Sciences·Luciana V RossoniDalton V Vassallo
Jun 9, 2014·The Journal of Thoracic and Cardiovascular Surgery·Daniele LinardiGiuseppe Faggian
Aug 21, 2007·Redox Report : Communications in Free Radical Research·Shinichi AsanoEric R Blough

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