PMID: 3545177Nov 1, 1986Paper

Left ventricular receptors: physiological controllers or pathological curiosities?

Basic Research in Cardiology
I H Zucker


Mechanically and chemically sensitive receptors in the ventricle have been described histologically and electrophysiologically. Early experiments documented the hypotension and bradycardia that resulted from the intracoronary administration of one of the veratrum alkaloids (the Bezold-Jarisch reflex). Mechanical distension of the ventricles also results in a reflex decrease in heart rate and a reduction in peripheral resistance. Skeletal muscle and coronary vascular resistance appear to be most prominently affected by stimulation of ventricular receptors. Coronary ischemia has also been shown to evoke reflex effects which are attributable to stimulation of ventricular receptors. The resultant bradycardia can be especially ominous in acute myocardial infarction. Changes in myocardial inotropic state have been shown to alter ventricular receptor discharge in experimental animals. This stimulus may evoke reflex changes in peripheral hemodynamics. A variety of humoral substances can alter ventricular receptor discharge and evoke Bezold-Jarisch like responses. These include bradykinin and prostaglandins. PGI2, when given intracoronary in small doses or intravenously in larger doses will lower blood pressure while inhibiting the baro...Continue Reading


May 18, 1978·The New England Journal of Medicine·P Needleman, G Kaley
Oct 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·T H HintzeG Kaley
Dec 1, 1977·The Journal of Physiology·I J FoxJ J Leonard
Nov 11, 1978·The American Journal of Physiology·J W PutneyB A Leslie
Sep 1, 1977·British Heart Journal·F Perez-Gomez, A Garcia-Aguado
Dec 1, 1975·Kidney International·A de TorrenteR W Schrier
Jul 1, 1986·The American Journal of Physiology·M J Holmberg, I H Zucker
Aug 1, 1985·Clinical Physiology·N H Secher, P Bie
Oct 14, 1971·The New England Journal of Medicine·D L EckbergE Braunwald
Jul 8, 1972·British Medical Journal·S W WebbJ F Pantridge
Dec 1, 1974·The Journal of Clinical Investigation·D L EckbergF M Abboud
Jan 1, 1973·Physiological Reviews·A S Paintal
May 1, 1973·The Journal of Clinical Investigation·A L MarkP G Schmid
Jul 1, 1973·The American Journal of Physiology·J A Armour
Feb 1, 1974·Circulation Research·D F Peterson, V S Bishop
Jul 1, 1974·The American Journal of Physiology·A L MarkU J Johannsen
Jun 1, 1972·The American Journal of Cardiology·H G HanleyN S Skinner
Jun 1, 1972·Acta Physiologica Scandinavica·B Oberg, P Thorén
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Chiba, A Yamauchi
Jul 11, 1971·The American Journal of Physiology·L A BrennanD E Roberts
May 1, 1968·The American Journal of Anatomy·B D Johnston
Jul 1, 1967·The American Journal of Physiology·T KolatatM J Oppenheimer
Oct 1, 1981·Circulation Research·I H Zucker, K G Cornish
Mar 1, 1983·Journal of Cardiovascular Pharmacology·W H NewmanP V Halushka
Jul 20, 1983·The American Journal of Cardiology·J Staszewska-Barczak
May 1, 1984·British Journal of Pharmacology·T H HintzeM J Panzenbeck
Sep 1, 1981·Cardiovascular Research·T H HintzeG Kaley

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