PMID: 18416294Apr 18, 2008Paper

Left ventricular remodelling and rebuilding of the infarcted area. Morphometric evaluation of the relationships between left ventricular mass, myocyte diameter, capillary density and fibrosis

Polskie Archiwum Medycyny Wewnętrznej
Marek PrechAndrzej Cieśliński

Abstract

The aim of the study was to assess the structural changes in both the infarcted region and free left ventricular (LV) wall that underly post-infarct LV remodeling in the human heart. Morphometric evaluation was performed in 31 human hearts, as follows: group I (control)--non-cardiac death (mean age: 52.4 +/- 11.2) and group II--post-Q-wave myocardial infarction (QMI) death (mean age: 58.8 +/- 9.4). The following morphological parameters were assessed: LV mass, infarct scar extent, stenosis of the infarct-related artery (IRA), myocyte diameter, myocyte nuclear diameter, myocyte nuclear density, density of the coronary network and LV fibrosis. Morphometric measurements were performed with the use of digital image analyser Leica Q500MC. A significant increase in the LV mass was noted in group II in comparison with the control group (296.0 +/- 81.3 g vs 150.2 +/- 18.6 g; p < 0.00001). LV hypertrophy was associated with: an increase in the myocyte diameter within the infarcted region (increase 61%) and free LV wall (increase 35%), an increase in the myocyte nuclear diameter (increase 28.1% and 11.2%, respectively), a reduction in the myocyte nuclear density (increase 52.9% and 34.4%, respectively), a reduction in the capillary densi...Continue Reading

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