Left ventricular response to isometric exercise in patients with denervated and innervated hearts

Circulation
W M SavinE B Stinson

Abstract

Patients with cardiac denervation resulting from allograft transplantation have been observed to increase their diastolic and systolic blood pressure during isometric exercise without concomitant cardioacceleration. To determine the mechanism for the blood pressure increase, heart rate, blood pressure, and ventricular volumes (measured using fluoroscopy of tantalum midwall myocardial markers) were recorded before and after a 50% maximal voluntary contraction. Seven cardiac transplant recipients (denervated heart) and seven nontransplant patients (innervated heart) were studied. Innervated and denervated heart patients increased systolic blood pressure by 16% and 21% and total peripheral resistance by 20% and 12%, respectively. The percentage responses were not significantly different between groups, except for heart rate, which increased 17% in innervated heart patients and 2% in denervated heart patients (p less than 0.05). Neither group had enhanced contractility or increases in cardiac output, suggesting that the blood pressure increases resulted in both groups from increased peripheral resistance.

References

Aug 1, 1967·The American Journal of Cardiology·G L EvansR H Eich
Feb 1, 1973·Analytical Biochemistry·P G Passon, J D Peuler
Jul 1, 1973·British Heart Journal·W GrossmanL Dexter
Dec 1, 1973·Clinical Science and Molecular Medicine·S KozlowskiM Franczyk
Sep 1, 1966·The American Journal of Cardiology·H R MacDonaldK W Donald
Sep 27, 1962·The New England Journal of Medicine·C A CHIDSEYE BRAUNWALD

❮ Previous
Next ❯

Citations

Oct 15, 1982·Archives of Biochemistry and Biophysics·S PontremoliB L Horecker
Apr 26, 1989·Biochimica Et Biophysica Acta·E C HeesbeenG E Staal
Apr 5, 1985·Biochimica Et Biophysica Acta·L BoscaE A Newsholme
Apr 1, 1982·Molecular and Cellular Endocrinology·P FisterW Schoner
Nov 28, 1984·Biochimica Et Biophysica Acta·J W AkkermanH Holmsen
Mar 1, 1989·British Heart Journal·S C RobsonR S Bexton
Oct 1, 1993·American Journal of Obstetrics and Gynecology·J W Van HookT J Benedetti
Jun 1, 1988·The American Journal of Cardiology·P W PflugfelderW J Kostuk
May 1, 1991·American Heart Journal·W von ScheidtG Autenrieth
Apr 15, 1988·The American Journal of Cardiology·D AlexopoulosM H Yacoub
Sep 1, 1981·The Physician and Sportsmedicine·P S Fardy
Feb 12, 1999·Scandinavian Journal of Medicine & Science in Sports·M KjaerN H Secher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
E Van SchaftingenH G Hers
Proceedings of the National Academy of Sciences of the United States of America
E Van Schaftingen, H G Hers
© 2021 Meta ULC. All rights reserved