Left ventricular systolic and diastolic function in aortic stenosis. Prognostic value after valve replacement and underlying mechanisms

European Heart Journal
O LundL H Kristensen

Abstract

The aims of the study were to examine the prognostic value of pre-operative left ventricular systolic and diastolic function on early, and late mortality after valve replacement for aortic stenosis, and to identify possible underlying mechanisms. Ninety-one prospectively recruited consecutive patients with a mean age of 61 years underwent valve replacement for aortic stenosis with concomitant coronary artery bypass grafting in 32 and a minimum postoperative observation period of 5.4 years. There were six early (< or = 30 days postoperatively) and 19 late deaths, and 18 deaths from specific causes (cardiac and prosthetic valve related). Early mortality occurred exclusively among patients with a combined subnormal left ventricular systolic function (subnormal ejection fraction or peak ejection rate, or supranormal time-to-peak ejection--duration of systole ratio) and a subnormal fast filling fraction. In Cox regression models on crude mortality and specific deaths, a subnormal ejection fraction and a fast filling fraction of < or = 45% were the only independent risk factors. Patients with none of these risk factors had normal sex- and age-specific survival, those with any one factor had an early, and those with both factors a mas...Continue Reading

Citations

Jan 18, 2006·Zeitschrift für Kardiologie·R R BrandtC W Hamm
Jan 29, 2008·Current Treatment Options in Cardiovascular Medicine·Matthew L Steinhauser, Peter H Stone
Jul 9, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Vito MannacioCarlo Vosa
Jun 26, 2003·The Annals of Thoracic Surgery·Ram SharonyStephen B Colvin
Jun 28, 2012·European Heart Journal Cardiovascular Imaging·L G KearneyP M Srivastava
Jul 31, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Marc R DweckSanjay K Prasad
Dec 30, 2008·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Peter P Th De JaegerePatrick W Serruys
May 20, 2014·Progress in Cardiovascular Diseases·Jeremy J ThadenMaurice Enriquez-Sarano
Jul 16, 2013·The International Journal of Cardiovascular Imaging·Flavio D'AscenziSergio Mondillo
Dec 10, 2008·Scandinavian Cardiovascular Journal : SCJ·Hans Kristian BrødløsMorten Smerup
Jul 24, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Enrico VizzardiLivio Dei Cas
Dec 2, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Eiichi HyodoRebecca T Hahn
Mar 1, 2011·The Annals of Thoracic Surgery·Apostolos TzikasPeter P T de Jaegere
Apr 15, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Davinder S JassalKwan L Chan
Jul 10, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Steen Hvitfeldt PoulsenHenrik Egeblad
Jun 5, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Michael BeckerRainer Hoffmann
Sep 7, 2007·Journal of Cardiac Surgery·Paolo CattaneoAndrea Sala
Feb 2, 2010·Echocardiography·Grace Casaclang-VerzosaPatricia A Pellikka
Mar 6, 2010·Annals of the New York Academy of Sciences·Noa BachnerDan Adam
Jun 5, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Joost M A A van der MaatenStefan G De Hert
Jan 31, 2006·Lancet·Lionel H OpieMarc A Pfeffer
May 6, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jinling ChenYuchi Han

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