Left Ventricular Trabeculations Decrease the Wall Shear Stress and Increase the Intra-Ventricular Pressure Drop in CFD Simulations

Frontiers in Physiology
Federica SaccoJazmin Aguado-Sierra

Abstract

The aim of the present study is to characterize the hemodynamics of left ventricular (LV) geometries to examine the impact of trabeculae and papillary muscles (PMs) on blood flow using high performance computing (HPC). Five pairs of detailed and smoothed LV endocardium models were reconstructed from high-resolution magnetic resonance images (MRI) of ex-vivo human hearts. The detailed model of one LV pair is characterized only by the PMs and few big trabeculae, to represent state of art level of endocardial detail. The other four detailed models obtained include instead endocardial structures measuring ≥1 mm2 in cross-sectional area. The geometrical characterizations were done using computational fluid dynamics (CFD) simulations with rigid walls and both constant and transient flow inputs on the detailed and smoothed models for comparison. These simulations do not represent a clinical or physiological scenario, but a characterization of the interaction of endocardial structures with blood flow. Steady flow simulations were employed to quantify the pressure drop between the inlet and the outlet of the LVs and the wall shear stress (WSS). Coherent structures were analyzed using the Q-criterion for both constant and transient flow ...Continue Reading

References

Sep 30, 2015·Computational and Mathematical Methods in Medicine·Seyed Saeid KhalafvandLiang Zhong
Feb 7, 2016·Computer Methods and Programs in Biomedicine·Siamak N DoostYosry S Morsi
Nov 5, 2016·Journal of Biomechanical Engineering·Jonas LantzTino Ebbers
Sep 12, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P KoullapisL Nicolaou

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Citations

Sep 4, 2020·Asian Cardiovascular & Thoracic Annals·Rabin Gerrah, Stephen J Haller
Aug 9, 2020·Journal of Biomechanical Engineering·Fanwei Kong, Shawn C Shadden
Aug 21, 2020·Nature·Hannah V MeyerDeclan P O'Regan
May 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Mohammadali HedayatIman Borazjani

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Methods Mentioned

BETA
imaging techniques

Key Resources (RRID) Mentioned

SCR_015734
SCR_002285
SCR_002552
SCR_015735
SCR_015736
SCR_002010
SCR_002516
SCR_015737
SCR_015854
SRC_015854

Software Mentioned

ITK
ParaView
Seg3D
Autodesk Meshmixer
Fiji
SNAP
Alya
Remesh
- SNAP Medical Image Segmentation Tool

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