Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure

Circulation
Octavio A VictalM B Ratcliffe

Abstract

Myocardial infarct expansion and left ventricular (LV) remodeling are integral components in the evolution of chronic heart failure and predict morbidity and mortality. Radiofrequency (RF) heating and patch placement of chronic LV aneurysms caused a sustained reduction in LV infarct area and volume in an ovine infarct model. This study evaluated the effect of RF heating and epicardial patch as an adjunct to coronary artery bypass graft on LV volumes in patients with prior myocardial infarction, evidence of akinetic/dyskinetic scar, and LV ejection fraction < or =40%. Ten patients (3 female; mean age, 64+/-11 years) scheduled for coronary artery bypass graft were enrolled (Canadian Cardiovascular Society angina class 2.1+/-1.1; New York Heart Association class 3.1+/-0.5). Intraoperative digital photography demonstrated an acute 39% reduction in infarct area (n=5; P=0.01), and transesophageal ECGs demonstrated a 16% acute reduction in LV end-diastolic volumes (n=9; P=0.002) after RF treatment. There were no intraoperative or procedure-related postoperative complications, and during an average follow-up of >180 days, there have been no safety issues. All patients had complete relief of their angina and improvement in exercise tole...Continue Reading

References

Jul 14, 1988·The New England Journal of Medicine·M A PfefferE Braunwald
Nov 1, 1969·American Heart Journal·H M ShanoffR Yano
Jan 4, 1998·Journal of Biomechanical Engineering·S S ChenJ D Humphrey
Jun 10, 1998·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·S L ObrzutM D Markel
Jul 21, 1999·Journal of Biomechanical Engineering·S S ChenJ D Humphrey
Nov 24, 1999·The American Journal of Cardiology·J R Teerlink, B M Massie
Jun 6, 2000·The Journal of Thoracic and Cardiovascular Surgery·M B RatcliffeR J Lee
Dec 29, 2000·Journal of the American College of Cardiology·M Ratcliffe

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Citations

May 12, 2004·Molecular and Cellular Endocrinology·Amy E RudolphEllen G McMahon
Nov 1, 2008·Journal of Interventional Cardiology·Jeffrey L WilliamsDavid Schwartzman
Jan 19, 2007·Journal of Cardiovascular Electrophysiology·Francisco G Cosio, Ernesto Castillo
Apr 1, 2004·The Surgical Clinics of North America·L Henry Edmunds
Jan 14, 2004·Critical Care Nursing Clinics of North America·Nancy M Albert
Oct 19, 2005·Journal of Dairy Science·M C Lagunas-SolarC Piña

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