PMID: 8593994Nov 1, 1995Paper

Left ventricular volumes and hemodynamic responses at onset of dynamic exercise with reduced venous return

Journal of Applied Physiology
A C NóbregaJ H Mitchell

Abstract

The hemodynamic effects of reducing venous return were assessed beat by beat at the onset of upright dynamic exercise. Mean arterial pressure (MAP), heart rate, and left ventricular end-systolic (ESV) and end-diastolic volumes (EDV; two-dimensional echocardiography) were measured in 10 healthy men during 20-s trials of upright cycling (30 W; 60 rpm). Exercise was performed either with or without venous occlusion of the legs (bilateral thigh cuffs inflated to 100 mmHg) in a random order. Without venous occlusion, MAP and cardiac output (CO) increased, and total peripheral resistance (TPR) decreased (P < 0.05) during the first approximately 10 beats after the onset of exercise. Initially, the CO response was accounted for by a rapid heart rate acceleration and, after approximately 15 cardiac cycles, by an increase in stroke volume, which occurred with a decrease in ESV and no change in EDV. With venous occlusion, EDV decreased and stroke volume did not rise during exercise. Thus the CO response was blunted by venous occlusion and MAP did not increase initially. However, after approximately 13 heart beats, MAP increased with no change in TPR. These findings suggest that compensatory mechanisms can elicit an increase in MAP at the ...Continue Reading

Citations

Aug 26, 2004·Experimental Physiology·Antonio CrisafulliAlberto Concu
Jan 19, 2016·Frontiers in Physiology·João S NevesAdelino F Leite-Moreira
Sep 5, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Igor A Fernandes, Lauro C Vianna
Oct 1, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Adrian LisBartłomiej Paleczny
Mar 4, 1999·Medicine and Science in Sports and Exercise·S A SmithP B Raven
Aug 31, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Joel D TrinityRussell S Richardson
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Dec 19, 2007·European Journal of Applied Physiology·Bruno M SilvaClaudio Gil Soares Araújo
Jul 20, 2007·European Journal of Applied Physiology·Norio HottaKoji Ishida
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Apr 12, 2019·Medicine and Science in Sports and Exercise·Omar IzemStéphane Nottin
Sep 18, 1997·Journal of Applied Physiology·A C NóbregaJ H Mitchell
Oct 20, 2001·Journal of Applied Physiology·K M GallagherP B Raven
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May 3, 2011·European Journal of Applied Physiology·K J Hackney, L L Ploutz-Snyder
Mar 16, 2002·Journal of Applied Physiology·Issei ShiotaniMasatsugu Hori

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