PMID: 8967395Apr 1, 1996Paper

Left ventricular volumetric conductance catheter for rats

The American Journal of Physiology
H ItoH Suga

Abstract

Left ventricular (LV) volume (V) is an essential parameter for assessment of the cardiac pump function. Measurement of LVV in situ by a conductance catheter method has been widely used in dogs and humans but not yet in small experimental animals such as rats. We instituted a miniaturized six-electrode conductance catheter (3-F) for rat LVV measurement and its signal processing apparatus. We compared stroke volumes (SVs) simultaneously measured with this conductance catheter introduced into the LV through the apex and an electromagnetic flow probe placed on the ascending aorta during gradual decreases in LVV by an inferior vena caval occlusion. A high and linear correlation (r = 0.982) was obtained between these differently measured by SVs pooled from six rats. In another group of three rats, LV pressure was simultaneously measured with a 3-F catheter-tip micromanometer introduced into the LV through the apex. We obtained the slope of the end-systolic pressure-volume (P-V) relationship (Emax) by a gradual ascending aortic occlusion. After administration of propranolol, Emax obviously decreased with no change in volume intercept of the P-V relationship. The conductance volumetry proved to be useful in rats.

Citations

May 9, 2008·The Journal of Physiological Sciences : JPS·Daisuke TakeshitaMiyako Takaki
Nov 16, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Wataru KoguchiToshihiko Ishimitsu
Nov 16, 2004·The Japanese Journal of Physiology·M Takaki
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ghassan S KassabHans Gregersen
Dec 13, 2006·Journal of Applied Physiology·David JeggerNikolaos Stergiopulos
Jan 21, 2003·The Japanese Journal of Physiology·Kazunori UemuraKenji Sunagawa
Aug 2, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yi SyuuHiroyuki Suga
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P A WhiteA N Redington
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yutaka KitagawaMiyako Takaki
Nov 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Kazunori UemuraKenji Sunagawa
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M D FeldmanG L Freeman
Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Munetaka ShibataMiyako Takaki
Jun 30, 2009·Basic & Clinical Pharmacology & Toxicology·Daisuke TakeshitaMiyako Takaki
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D Georgakopoulos, D A Kass

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.