Leftover opioids following adult surgical procedures: a systematic review and meta-analysis.

Systematic Reviews
Lori SchirleStephen Bruehl

Abstract

US opioid prescribing and use escalated over the last two decades, with parallel increases in opioid misuse, opioid-related deaths, and concerns about diversion. Postoperatively prescribed opioids contribute to these problems. Policy makers have addressed this issue by limiting postoperative opioid prescribing. However, until recently, little data existed to guide prescribers on opioid needs postoperatively. This meta-analysis quantitatively integrated the growing literature regarding extent of opioids leftover after surgery and identified factors associated with leftover opioid proportions. We conducted a meta-analysis of observational studies quantifying postoperative opioid consumption in North American adults, and evaluated effect size moderators using robust variance estimation meta-regression. Medline, EMBASE, Cumulative Index of Nursing and Allied Health Literature, and Cochrane Database of Systematic Reviews were searched for relevant articles published January 1, 2000 to November 10, 2018. The Methodological Index for Non-Randomized Studies (MINORS) tool assessed risk of study bias. The proportion effect size quantified the primary outcome: proportion of prescribed postoperative opioids leftover at the time of follow-u...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 11, 2003·The Clinical Journal of Pain·Arnold R GammaitoniSuzette Bergmark
Feb 20, 2004·The Journal of Knee Surgery·Paul R BeckJennifer K Hayden
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Mar 7, 2006·The Journal of Pain : Official Journal of the American Pain Society·Robert N JamisonJohn C Baird
Sep 1, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H GehaJ L Beziat
Apr 29, 2010·Journal of Advanced Nursing·Claire G OlderMandy Layzell
Mar 14, 2012·The Journal of Hand Surgery·Jeffrey RodgersEdward Finnerty
Feb 5, 2013·The Journal of Pain : Official Journal of the American Pain Society·Stephen BruehlYu Lin
Apr 22, 2015·American Journal of Preventive Medicine·Benjamin LevyChristopher M Jones
May 11, 2016·Annals of Surgery·Xueying JiangRenyu Liu
Jul 13, 2016·Female Pelvic Medicine & Reconstructive Surgery·Carolyn W SwensonMitchell B Berger
Oct 30, 2016·Drug and Alcohol Dependence·Brandon C MaughanKarin V Rhodes
Jan 7, 2017·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Jan 14, 2017·Hand : Official Journal of the American Association for Hand Surgery·Talia ChapmanAsif M Ilyas
Feb 10, 2017·The American Journal of Sports Medicine·Kanupriya KumarChristopher L Wu
Apr 14, 2017·JAMA Surgery·Chad M BrummettBrahmajee K Nallamothu
Jun 9, 2017·Obstetrics and Gynecology·Brian T BatemanLisa R Leffert
Aug 3, 2017·JAMA Surgery·Mark C BicketChristopher L Wu
Sep 11, 2017·International Urogynecology Journal·Lekha S HotaMichele R Hacker
Oct 28, 2017·Foot & Ankle International·Akash GuptaScott J Ellis
Nov 2, 2017·Hand : Official Journal of the American Association for Hand Surgery·Andrew MillerJonas L Matzon
Nov 10, 2017·JAMA Facial Plastic Surgery·Sagar PatelRussell Kridel
Nov 11, 2017·The Journal of Hand Surgery·Blair PetersAvinash Islur
Dec 5, 2017·Journal of the American College of Surgeons·Maureen V HillRichard J Barth
Dec 8, 2017·Annals of Surgery·Adina E FeinbergUNKNOWN Best Practice in Surgery Group
Dec 25, 2017·The Journal of Hand Surgery·Jeffrey G StepanRyan P Calfee
Jan 24, 2018·The Journal of Obstetrics and Gynaecology Research·Payton SchmidtCarolyn W Swenson
Feb 6, 2018·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Daniel CunninghamRichard Mather
Feb 7, 2018·The Journal of Bone and Joint Surgery. American Volume·Matthew J SabatinoDavid S Jevsevar
Mar 3, 2018·Journal of the American College of Surgeons·Mayo H FujiiCharles D MacLean

❮ Previous
Next ❯

Citations

Feb 16, 2021·Journal of Environmental Management·Christine VatovecKati Gallagher
Feb 27, 2021·Expert Opinion on Pharmacotherapy·Katarina Kojic, Hance Clarke
Jun 12, 2021·The Clinical Journal of Pain·Nabarun DasguptaChris Delcher
Jul 31, 2021·Contraception·Liza R GibbsElizabeth M Garry

❮ Previous
Next ❯

Software Mentioned

R
OvidSP
MINORS
PRISMA
Methodological Index for Non - Randomized Studies ( MINORS )
clubSandwich
robumeta

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.