Leg movements during wakefulness in restless legs syndrome: time structure and relationships with periodic leg movements during sleep

Sleep Medicine
Raffaele FerriMarco Zucconi

Abstract

Approximately one third of patients with restless legs syndrome (RLS) also show periodic leg movements (PLM) during relaxed wake fulness (PLMW). In contrast with the large amount of data published on periodic leg movements during sleep (PLMS), PLMW have received less attention from the scientific community. The objective of this study was to evaluate the correlations/differences of time-structure and response to a dopamine-agonist between PLMW and PLMS in patients with RLS. Ninety idiopathic RLS patients and 28 controls were recruited. Subjects underwent clinical and neurophysiological evaluation, hematological screening, and one or two consecutive full-night polysomnographic studies. A subset of patients received 0.25mg of pramipexole or placebo before the second recording. Polysomnographic recordings were scored and LM activity was analyzed during sleep and during the epochs of wakefulness occurring during the first recording hour. RLS patients had higher LM activity during wakefulness than controls, but with a similar periodicity. Even if correlated, the ability of the PLMW index to predict the PLMS index decreased with increasing LM activity. Intermovement intervals during wakefulness showed one peak only at approximately 4...Continue Reading

References

May 1, 1992·Electroencephalography and Clinical Neurophysiology·B KempJ Gade
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J MontplaisirG Lavigne
Feb 9, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Martin MichaudJacques Montplaisir
May 3, 2002·Journal of Neurology·Thomas C WetterClaudia Trenkwalder
Oct 3, 2003·Journal of Pineal Research·Gotthard G TriblJosef Zeitlhofer
Nov 1, 2003·Sleep Medicine·Arthur S WaltersUNKNOWN International Restless Legs Syndrome Study Group
Jun 3, 2006·Sleep Medicine·Murat AksuWilliam Bara-Jimenez
Jan 20, 2007·Sleep Medicine·Stephany Fulda, Thomas C Wetter
May 22, 2007·Sleep Medicine·Mauro ManconiLuigi Ferini-Strambi
Dec 13, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Minori EnomotoMasato Matsuura
Mar 4, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Mauro ManconiLuigi Ferini-Strambi

❮ Previous
Next ❯

Citations

Apr 17, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Raffaele FerriGiuseppe Plazzi
Nov 17, 2015·Current Medical Research and Opinion·Diego Garcia-BorregueroJohn Winkelman
Mar 5, 2016·Acta Neurologica Scandinavica·M C TrindadeG G Tribl
Mar 28, 2013·Journal of Sleep Research·Maria A T CippàEsther Werth
Jul 29, 2015·Nature Reviews. Neurology·Claudia TrenkwalderWalter Paulus
Oct 27, 2015·Sleep Medicine·Jason LiEmmanuel Mignot
Nov 24, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matt T Bianchi, Robert J Thomas
Dec 10, 2014·PloS One·Hyatt MooreEmmanuel Mignot
Dec 26, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Raffaele FerriBirgit Högl
Dec 5, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Raffaele FerriLuigi Ferini-Strambi
Jul 18, 2019·Journal of Sleep Research·Raffaele FerriOliviero Bruni
May 28, 2020·International Journal of Environmental Research and Public Health·Giuseppe DidatoPaola Lanteri
May 15, 2021·Sleep Medicine Clinics·Marco ZucconiAndrea Galbiati

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.