Leg ulcers in sickle cell disease: A retrospective study of 40 cases

Annales de dermatologie et de vénéréologie
M NdiayeA Kane

Abstract

In Africa, studies primarily devoted to chronic leg ulcer due to sickle cell disease are rare. The objectives of the study were to determine the epidemiology, diagnosis and progression of chronic leg ulcers in sickle cell disease. A 5-year multicentre, retrospective study was conducted in three university hospitals in Dakar. We included all patients with chronic leg ulcers occurring in a setting of sickle cell disease. We identified 40 cases of chronic leg ulcers associated with sickle cell disease, representing 3.4% of the current population of sickle cell patients in our institutions. The average patient age was 25.9 years and the sex ratio was 2.33. Chronic leg ulcer was the presenting feature enabling diagnosis of sickle cell disease in one third of the cases. The average time to consultation from onset was 5.4 years. Pain was reported in 22 cases (48%). Ulcers were isolated in 76% and multiple in 24% of cases. The most common site was the medial malleolus (39%). A CBC allowed identification of anaemia in 35 cases. Haemoglobin electrophoresis was performed and homozygous sickle cell SS disease was identified in 39 cases and heterozygous SC disease in 1 case. Local treatments included physiologic serum, topical antibiotics a...Continue Reading

References

Oct 31, 2002·British Journal of Haematology·Andrea ClareGraham R Serjeant
Oct 20, 2004·Advances in Skin & Wound Care·Jennifer T Trent, Robert S Kirsner
Feb 25, 2006·Gynécologie, obstétrique & fertilité·UNKNOWN Haute Autorité de Santé
Nov 23, 2007·Annales de dermatologie et de vénéréologie·S-O NiangB Ndiaye
Sep 28, 2010·American Journal of Hematology·Caterina P MinnitiSamir K Ballas

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