Legacy and alternative per- and polyfluoroalkyl substances in the U.S. general population: Paired serum-urine data from the 2013-2014 National Health and Nutrition Examination Survey.

Environment International
Antonia M CalafatLee-Yang Wong

Abstract

Concerns are heightened from detecting environmentally persistent man-made per- and polyfluoroalkyl substances (PFAS) in drinking water systems around the world. Many PFAS, including perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), remain in the human body for years. Since 1999-2000, assessment of exposure to PFOS, PFOA, and other select PFAS in the U.S. general population has relied on measuring PFAS serum concentrations in participants of the National Health and Nutrition Examination Survey (NHANES). Manufacturers have replaced select chemistries ("legacy" PFAS) with PFAS with shorter biological half-lives (e.g., GenX, perfluorobutanoate [PFBA]) which may efficiently eliminate in urine. However, knowledge regarding exposure to these compounds is limited. We analyzed 2682 urine samples for 17 legacy and alternative PFAS in 2013-2014 NHANES participants ≥6 years of age. Concentrations of some of these PFAS, measured previously in paired serum samples from the same NHANES participants, suggested universal exposure to PFOS and PFOA, and infrequent or no exposure to two short-chain PFAS, perfluorobutane sulfonate and perfluoroheptanoate. Yet, in urine, PFAS were seldom detected; the frequency of not having detectabl...Continue Reading

Citations

Mar 7, 2020·Environmental Science. Processes & Impacts·Clara M A Eichler, John C Little
Mar 8, 2020·International Journal of Environmental Research and Public Health·Alexis M TemkinLisa M Kamendulis
Dec 10, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Katherine von Stackelberg, Pamela R D Williams
Jan 28, 2021·International Journal of Molecular Sciences·Richard A BraseDavid C Spink
Feb 7, 2021·Environment International·Yuqing WangJun Zhang
Oct 11, 2020·Environmental Research·Hannah GardenerPhilippe Grandjean
Jun 26, 2021·Environment International·Jenny L CarwileAbby F Fleisch

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