Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances.

Journal of Assisted Reproduction and Genetics
Gary LevyWilliam H Catherino

Abstract

Uterine leiomyomas are common, benign, reproductive tract tumors affecting a majority of reproductive aged women. They are associated with gynecologic morbidity and detrimentally affect reproductive potential. The etiology of leiomyomas is poorly understood and their diagnosis prior to treatment with Assisted Reproductive Technologies (ART) represents a management dilemma. The purpose of this paper is to review known genetic and molecular contributions to the etiologies of leiomyomas, describe their impact on ART outcomes and reproductive potential, and review alternative therapies and future directions in management. A critical review of the literature pertaining to genetic component of uterine leiomyomas, their impact on ART and pregnancy and leiomyoma therapeutics was performed. Uterine leiomyomas are characterized by complex molecular mechanisms. Their location and size determines their potential detriment to ART and reproductive function and novel therapeutic modalities are being developed. The high prevalence of uterine leiomyomas and their potential detrimental influence on ART and reproductive function warrants continued well-designed studies to ascertain their etiology, optimal treatment and novel less morbid therapies.

References

May 1, 1989·American Journal of Obstetrics and Gynecology·J P RiceB S Mahony
Oct 1, 1981·Fertility and Sterility·V C Buttram, R C Reiter
Sep 1, 1994·American Journal of Perinatology·P VerganiC Mangioni
May 1, 1994·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·N StrobeltP Vergani
Jan 1, 1996·Fertility and Sterility·L M KettelS S Yen
Nov 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·E M VikhlyaevaN D Fantschenko
Aug 1, 1996·The Journal of the American Association of Gynecologic Laparoscopists·C E MillerM Rundell
Aug 1, 1994·The Journal of the American Association of Gynecologic Laparoscopists·R NarayanK Goswamy
Mar 13, 1998·Fertility and Sterility·I BrosensH Van den Berghe
Mar 24, 1998·Molecular Human Reproduction·M S ReinC C Morton
Jun 17, 1998·The Journal of Clinical Endocrinology and Metabolism·H SniederT D Spector
Apr 1, 1999·The Australian & New Zealand Journal of Obstetrics & Gynaecology·W E RobertsJ N Martin
Jul 31, 1999·Fertility and Sterility·P VercelliniP G Crosignani
Aug 4, 1999·Obstetrics and Gynecology·N N VarastehM D Keltz
Apr 25, 2000·Obstetrics and Gynecology·G D CoronadoS M Schwartz
May 5, 2000·The Cochrane Database of Systematic Reviews·A LethabyM Sowter
Oct 19, 2000·Environmental Health Perspectives·D L Healy
Dec 29, 2000·Human Reproduction Update·N Bajekal, T C Li
May 10, 2001·Clinical Obstetrics and Gynecology·K L Gross, C C Morton
Jun 19, 2001·The Cochrane Database of Systematic Reviews·A LethabyM Sowter
Aug 7, 2001·Journal of Clinical Ultrasound : JCU·C B BensonP M Doubilet
Aug 10, 2001·Obstetrical & Gynecological Survey·E A Pritts
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yun Kyoung KangRobert G Roeder
Jun 4, 2002·Human Reproduction·J Donnez, P Jadoul
Feb 21, 2003·Journal of the Society for Gynecologic Investigation·Frédéric AmantEric F P M Schoenmakers
Sep 13, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sebastiano CampoPietro Gambadauro
Apr 22, 2004·The Journal of Reproductive Medicine·Eyal SheinerMoshe Mazor
Jul 9, 2004·Fertility and Sterility·Mauro MarchionniTommaso Susini
Aug 6, 2004·American Journal of Obstetrics and Gynecology·Jay GoldbergRenato Seracchioli
Nov 18, 2004·AJR. American Journal of Roentgenology·Jonathan HindleyFerenc Jolesz
Feb 26, 2005·Annals of the New York Academy of Sciences·Carlo BullettiMarco Stefanetti
Mar 19, 2005·Gynecologic and Obstetric Investigation·C BeneckeD W Steyn
May 4, 2005·Fertility and Sterility·Eric S SurreyWilliam B Schoolcraft
May 20, 2005·Reproductive Biomedicine Online·Luca GianaroliAnna Pia Ferraretti
Jun 1, 2005·Journal of Minimally Invasive Gynecology·Steven H EisingerDavid S Guzick
Jun 11, 2005·Science·Cheryl Lyn Walker, Elizabeth A Stewart

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Citations

Oct 1, 2013·Human Reproduction Update·Reshef Tal, James H Segars
Jul 12, 2014·Journal of Cell Communication and Signaling·Caitlin Fujisawa, John J Castellot
Dec 4, 2012·Fertility and Sterility·Gary LevyAlicia Y Armstrong
Aug 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang ShenMulan Ren
Apr 6, 2013·Fertility and Sterility·Md Soriful IslamPasquapina Ciarmela
May 6, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yang ShenQian Xu
Feb 16, 2015·Obstetrics and Gynecology Clinics of North America·Carter Owen, Alicia Y Armstrong
May 1, 2016·Human Reproduction·Faezeh KoohestaniRomana A Nowak
Oct 22, 2014·Reproductive Sciences·Lisa N BrunengraberPhyllis C Leppert
Feb 15, 2018·The Journal of Biological Chemistry·Min Ju ParkThomas G Boyer
Nov 5, 2015·Current Opinion in Obstetrics & Gynecology·Stefano R GiannubiloPasquapina Ciarmela
Apr 7, 2020·Scientific Reports·Ana SalasTeresa A Almeida
Apr 1, 2020·Journal of Gynecologic Surgery·Charles E Miller, Khadra M Osman
Jan 24, 2020·The New England Journal of Medicine·William D SchlaffOzgul Muneyyirci-Delale
Jun 1, 2021·Abdominal Radiology·Rishi Philip MathewShameema Anvarsadath
Jul 16, 2021·Journal of Minimally Invasive Gynecology·Rosanne M KhoXiao Xu

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