Leiomyoma of the adrenal gland presenting as a non-functioning adrenal incidentaloma: case report and review of the literature

Endocrine Pathology
Jingmei LinThomas J Giordano

Abstract

A 31-year-old woman was incidentally found to have a large right adrenal mass by computed tomography imaging and underwent a workup that included endocrinological evaluation and positron emission tomography imaging. Laboratory results revealed the mass to be non-functioning. Imaging studies revealed a 9-cm heterogeneous mass that was not FDG avid. Because of concern for adrenal cortical carcinoma, the patient underwent a successful right adrenalectomy. Pathology examination demonstrated an 11-cm circumscribed mass consisting of uniform spindle cells without nuclear pleomorphism, necrosis, or mitotic activity. The diagnosis of leiomyoma was supported by a panel of immunohistochemical stains. Adrenal leiomyomas have been reported in the literature, although most are small and not preoperatively suspicious for malignancy. This case illustrates that benign tumors such as leiomyomas, when large and heterogeneous on imaging, can clinically mimic adrenal cortical carcinomas and should be included in the differential diagnosis of adrenal incidentalomas.

References

Sep 1, 1992·AJR. American Journal of Roentgenology·D R Radin, M Kiyabu
Jul 1, 1991·Pediatric Hematology and Oncology·F MouchetG Cornu
Jan 1, 1995·Surgery Today·S NishidaM Tokunaga
Oct 1, 1994·Clinical Imaging·R L Goldman, P A Brodey
May 1, 1994·Abdominal Imaging·H DahanR Rymer
Jan 1, 1993·International Urology and Nephrology·R L Goldman, P A Brodey
Jan 1, 1994·Journal of Computer Assisted Tomography·R H WachsbergA Adekosan
Nov 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·J A Jimenez-HeffernanM Nistal
Apr 1, 1996·Postgraduate Medical Journal·J Newell-Price, A Grossman
Nov 10, 1998·Journal of Surgical Oncology·I A Jacobs, S A Kagan
Jun 26, 1999·Pediatric Radiology·D L RosenfeldS J Underberg-Davis
Sep 27, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G ArnaldiF Mantero
Dec 20, 2002·Current Opinion in Oncology·Geoffrey B Thompson, William F Young
Mar 5, 2003·Annals of Internal Medicine·Melvin M GrumbachH Samuel Wieand
Jun 16, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Georg ZettinigKurt Kletter
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Franco Mantero, Nora Albiger
May 16, 2006·Journal of Endocrinological Investigation·S BovioM Terzolo
May 23, 2006·Clinical Nuclear Medicine·Gustavo S P MeirellesTimothy Akhurst
Sep 28, 2006·Hormones : International Journal of Endocrinology and Metabolism·Dimitrios A Linos
Nov 18, 2006·The Kaohsiung Journal of Medical Sciences·Tu-Hao ChangWen-Jeng Wu
Mar 9, 2007·International Journal of Clinical Practice·S-J HanS-K Lim

❮ Previous
Next ❯

Citations

Apr 10, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Pragati A SatheBhuvaneshwari M Kandalkar
Jan 29, 2013·Pediatric Surgery International·Sandesh V ParelkarSanjay N Oak
Apr 23, 2009·Journal of Cellular Physiology·Kyu Won Jung
Aug 3, 2021·International Journal of Surgery Case Reports·Sujan SharmaSansar Babu Tiwari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Related Papers

World Journal of Surgery
L M Brunt, J F Moley
Annals of the Royal College of Surgeons of England
J GoddardD H Markham
Journal of the American College of Radiology : JACR
Peter L Choyke, ACR Committee on Appropriateness Criteria
© 2021 Meta ULC. All rights reserved