Leiomyosarcoma After Liver Transplantation Is Unrelated to Epstein-Barr Virus: A Case Report

Transplantation Proceedings
J ZhangS Zhou

Abstract

De novo malignancy is a severe complication after liver transplantation (LT), but de novo leiomyosarcoma is extremely rare. We reported de novo leiomyosarcoma occurring after LT. The patient's status for Epstein-Barr virus was negative. The donor was a 21-year-old man with a central nervous system malignancy who underwent surgery. Three months later brain death occurred and his organs were donated. Leiomyosarcoma in the recipient was detected shortly after LT. It progressed after minimization of immunosuppression and apatinib therapy, and the patient died of cachexia 17 months after LT. De novo leiomyosarcoma is a rare but serious event after LT, needing comprehensive management.

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