Leiomyosarcoma in soft tissue: examination of p53 status and cell proliferating factors in different locations

Human Pathology
T KonomotoMasazumi Tsuneyoshi

Abstract

The biological behavior of soft tissue leiomyosarcoma varies with its location: tumors in deep soft tissue show a worse prognosis than those in superficial soft tissue. In this study, we analyzed cell proliferating factors (mitotic and Ki-67 indices) and the p53 status of both types of leiomyosarcoma (37 cases) to evaluate the possibility that these factors may serve as indicators in prognosis. Expression of both of the cell proliferating factors were higher in the superficial type, but these differences were not significant. The incidence of abnormal p53 detected by immunohistochemistry and mutation analysis was also higher in the superficial type, but, again, no significant difference was observed. Abnormal p53 and a high Ki-67 index in the deep type, and a large tumor size (>6 cm) in the superficial type may be useful as prognostic factors. Interestingly, all of the superficial cases who died of the disease showed abnormal p53. In conclusion, these two types of leiomyosarcoma are essentially the same, and their location remains a good prognostic factor. Furthermore, abnormality of the p53 gene was related to a poor prognosis regardless of the tumor's anatomic location.

References

Jul 2, 1992·Nature·D P Lane
Jul 2, 1992·Nature·G FarmerC Prives
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L M MulliganW K Cavenee
Jan 1, 1990·La Chirurgia degli organi di movimento·R J ZehrA Weltevreden
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Jul 16, 1985·Biochemical and Biophysical Research Communications·S E GoelzB Vogelstein
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·J GerdesH Stein
Mar 1, 1996·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·A H ReidT J O'Leary

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Citations

Sep 15, 2016·Neurology India·Ankush GuptaVedantam Rajshekhar
May 11, 2002·Breast Cancer Research and Treatment·Maria do Socorro MacielM Mitzi Brentani
Mar 17, 2009·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Leonard A CohenLlewellyn J Cornelius
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cheng-Han LeeC Blake Gilks
Sep 28, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y OdaM Tsuneyoshi
Jun 16, 2012·Clinical & Experimental Metastasis·Elisabetta PennacchioliGiovanni Mazzarol
Oct 1, 2013·Cancer Control : Journal of the Moffitt Cancer Center·Jeremiah L DeneveJonathan S Zager
Nov 16, 2019·International Journal of Dermatology·Viktoryia KazlouskayaAmor Khachemoune
Aug 25, 2001·Archives of Pathology & Laboratory Medicine·S X LiangZ Jiang
Sep 17, 2021·Veterinary Pathology·Francisco Rodríguez Guisado, Pedro Luis Castro

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