Leishmania amazonensis hijacks host cell lysosomes involved in plasma membrane repair to induce invasion in fibroblasts

Journal of Cell Science
Victor Soares Cavalcante-CostaThiago Castro-Gomes

Abstract

Intracellular parasites of the genus Leishmania are the causative agents of leishmaniasis. The disease is transmitted by the bite of a sand fly vector, which inoculates the parasite into the skin of mammalian hosts, including humans. During chronic infection the parasite lives and replicates inside phagocytic cells, notably the macrophages. An interesting, but overlooked finding, is that other cell types and even non-phagocytic cells have been found to be infected by Leishmania spp. Nevertheless, the mechanisms by which Leishmania invades such cells had not been previously studied. Here, we show that L. amazonensis can induce their own entry into fibroblasts independently of actin cytoskeleton activity, and, thus, through a mechanism that is distinct from phagocytosis. Invasion involves subversion of host cell functions, such as Ca2+ signaling and recruitment and exocytosis of host cell lysosomes involved in plasma membrane repair.This article has an associated First Person interview with the first author of the paper.

References

Sep 1, 1985·The American Journal of Tropical Medicine and Hygiene·J D Schwartzman, R D Pearson
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M CollotS J Singer
Mar 1, 1994·The Journal of Experimental Medicine·I TardieuxN W Andrews
Jul 1, 1996·The Journal of Cell Biology·A RodríguezN W Andrews
Jul 1, 1996·Veterinary Pathology·J Hervás RodríguezJ C Gómez-Villamandos
Feb 1, 1997·FEMS Microbiology Letters·P Valentin-WeigandG S Chhatwal
Apr 7, 1997·The Journal of Cell Biology·A RodríguezN W Andrews
Jun 20, 2000·Parasitology Today·M G Rittig, C Bogdan
Jun 22, 2000·The Journal of Experimental Medicine·C BogdanM G Rittig
Mar 10, 2001·European Journal of Immunology·C L BennettC C Blackburn
May 30, 2002·Molecular and Biochemical Parasitology·Rodrigo P P SoaresSalvatore J Turco
Jun 5, 2003·Trends in Microbiology·Tamás LaskayWerner Solbach
Jul 12, 2005·International Journal for Parasitology·Yanji Xu, Louis M Weiss
May 23, 2007·Autoimmunity·G van ZandbergenT Laskay
Mar 5, 2008·The Journal of Cell Biology·Vincent IdoneNorma W Andrews
May 9, 2008·The Journal of Biological Chemistry·Noushin NabaviRene E Harrison
Sep 10, 2009·FEBS Letters·Thiago Castro-GomesMaria Fátima Horta
Jun 10, 2010·The Journal of Cell Biology·Christina TamNorma W Andrews
May 4, 2011·Cellular Microbiology·Sébastien BesteiroMaryse Lebrun
May 4, 2011·The Journal of Experimental Medicine·Maria Cecilia FernandesNorma W Andrews
Aug 31, 2011·Journal of Visualized Experiments : JoVE·Jialie LuoHongzhen Hu
Oct 4, 2015·Seminars in Cell & Developmental Biology·N W AndrewsT Castro-Gomes
Apr 18, 2016·Current Opinion in Cell Biology·Tanya J Shaw, Paul Martin
Jun 22, 2016·The Journal of Cell Biology·Marisa EncarnaçãoOtília V Vieira
Jun 7, 2017·PLoS Neglected Tropical Diseases·Natália Fernanda CoutoLuciana O Andrade
Nov 22, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matheus B H CarneiroNathan C Peters
Nov 25, 2017·International Journal of Medical Microbiology : IJMM·Stefan SchilleGer van Zandbergen
Aug 22, 2018·Lancet·Sakib BurzaMarleen Boelaert

❮ Previous
Next ❯

Citations

Feb 23, 2020·Journal of Cell Science·Maria Fátima HortaThiago Castro-Gomes
Jun 27, 2020·Frontiers in Cell and Developmental Biology·Marina Ferreira BatistaDiana Bahia
Mar 5, 2021·Bio-protocol·Natália Fernanda do CoutoLuciana Oliveira Andrade

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.