Leishmania chagasi naturally resistant to nitric oxide isolated from humans and dogs with visceral leishmaniasis in Brazil

Nitric Oxide : Biology and Chemistry
P L SantosRoque P Almeida

Abstract

Nitric oxide (NO) plays an important role as a leishmanicidal agent in murine macrophages. NO resistant Escherichia coli and Mycobacterium tuberculosis have been associated with poor outcomes of their resulting diseases. NO resistant Leishmania braziliensis has also been identified and exacerbates the clinical course of human leishmaniasis. We report, for the first time, natural resistance of Leishmania chagasi promastigotes to NO. These parasites were isolated from humans and dogs with visceral leishmaniasis. We also demonstrate that this resistance profile was associated with a greater survival capacity and a greater parasite burden in murine macrophages, independent of activation and after activation by IFN-γ and LPS.

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Citations

Oct 8, 2013·Parasitology Research·Alana Freire de AzevedoRoberta Pereira Miranda Fernandes
Oct 7, 2015·Trends in Parasitology·Romain Olekhnovitch, Philippe Bousso
Nov 27, 2015·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Gustavo A C BarrosRui Seabra Ferreira
Apr 16, 2020·Parasite Immunology·Gabriela Pessenda, João Santana da Silva
Jan 23, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin PaduchChristian Bogdan
Jan 31, 2018·Frontiers in Immunology·Nalu Teixeira de Aguiar PeresRoque Pacheco de Almeida
Dec 20, 2019·PLoS Neglected Tropical Diseases·Ana Nilce S Maia-ElkhouryManuel J Sanchez-Vazquez
May 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ehab Kotb ElmahallawyAmira A Saleh
Jul 18, 2021·Parasitology Research·Lucas Sousa MagalhãesTatiana Rodrigues de Moura

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