Leishmania immune adherence reaction in vertebrates

Parasite Immunology
M Domínguez, A Toraño

Abstract

In normal human blood, C3-opsonized Leishmania promastigotes immune adhere to erythrocytes, a mechanism believed to enhance their clearance from blood and phagocytosis. Given the potential importance of this reaction in host defence against infection, the promastigote-erythrocyte interaction was studied in blood of individuals from one avian and 12 mammalian genera; [111In]-labelled promastigotes were found to bind only to primate erythrocytes. Nevertheless, previous experiments coincubating platelets isolated from nonprimate mammals with C3-opsonized promastigotes led to promastigote-platelet adherence. To ascertain whether this is a natural mechanism in nonprimate Leishmania infection, normal blood from members of Leishmania animal models of interest, dog, guinea-pig, hamster, mouse and rabbit, was infected ex vivo with promastigotes. Within 1 min of blood contact, the promastigote surface was loaded with platelets, rapidly evolving into large aggregates. These results confirm the physiological nature of the reaction and demonstrate that promastigote-erythrocyte and promastigote-platelet binding are the first parasite-host cell encounters after Leishmania invasion of primates and nonprimate mammals, respectively. Leishmania i...Continue Reading

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Citations

Aug 6, 2011·Seminars in Immunopathology·Adriana Vieira-de-AbreuGuy A Zimmerman
May 22, 2003·Microbes and Infection·Mercedes DomínguezAlfredo Toraño
Jul 21, 2010·PLoS Neglected Tropical Diseases·Inmaculada MorenoAlfredo Toraño
Feb 21, 2002·The Journal of Experimental Medicine·Mercedes DomínguezAlfredo Toraño
May 25, 2011·The Journal of Experimental Medicine·Ricardo GoncalvesDavid M Mosser
Jan 13, 2006·Veterinary Immunology and Immunopathology·G TerrazzanoP Ciaramella
Feb 6, 2004·Memórias do Instituto Oswaldo Cruz·M C de AlmeidaM Barral-Netto
Apr 2, 2013·Journal of Leukocyte Biology·Rachel PolandoMary Ann McDowell
Apr 1, 2021·Annual Review of Biomedical Engineering·Jacob S BrennerVladimir R Muzykantov

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