Leishmania infecting man and wild animals in Saudi Arabia. 8. The influence of prior infection with Leishmania arabica on challenge with L. major in man

Transactions of the Royal Society of Tropical Medicine and Hygiene
W PetersF Y Liew

Abstract

A clinical trial is described of an attempt to protect against Leishmania major by prior vaccination with live L. arabica. After a single, previously leishmanin-negative, adult male volunteer was bitten by 8 Phlebotomus papatasi infected with L. arabica, no infected lesions were observed. He remained leishmanin-negative and his lymphocytes reacted weakly to antigens of L. arabica or L. major. Subsequently he and 3 other leishmanin-negative adult male volunteers were vaccinated with cultures containing 4 x 10(6) promastigotes of L. arabica. All remained leishmanin-negative but their lymphocytes showed some response to both L. arabica and L. major antigens. 96 d after vaccination these 4, and another, non-vaccinated, volunteer were challenged with 2 x 10(6) promastigotes of L. major. Active cutaneous, ulcerated lesions developed in all 5 volunteers. The lesions in 3 vaccinated volunteers were associated with marked lymphadenitis and beading, but the lesions started to heal spontaneously within 120-250 d after challenge. The lesion in the fourth vaccinated volunteer was less severe and lymphadenitis was not observed. The lesion in the unvaccinated subject developed more slowly and was smaller, but more chronic, than those in the v...Continue Reading

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Citations

Jun 1, 1995·Parasitology Today·R L Jacobson
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·R G TitusS M Beverley
Jan 16, 2013·Annual Review of Entomology·Paul D Ready
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carmel B StoberJenefer M Blackwell
Oct 20, 2021·Expert Review of Vaccines·Vivak ParkashCharles J Lacey

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