PMID: 11899433Mar 20, 2002Paper

Leishmania major lipophosphoglycan modulates the phenotype and inhibits migration of murine Langerhans cells

Immunology
A Ponte-SucreH Moll

Abstract

Langerhans cells (LC), members of the dendritic cell family, play a central role in the initiation and regulation of the immune response against the protozoan parasite Leishmania major. LC take up antigens in the skin and transport them to the regional lymph nodes for presentation to T cells. However, it is not known whether LC functions are modulated by parasite antigens. In the present study, we examined the effect of a major parasite surface molecule, L. major lipophosphoglycan (LPG), on the maturation of LC and their migratory properties. The results show that exposure to LPG did not affect the expression of major histocompatibility complex (MHC) class II and B7, but induced an up-regulation of CD25, CD31 and vascular endothelial (VE)-cadherin expression and a down-regulation of Mac-1 expression, by LC. Importantly, LPG treatment inhibited the migratory activity of LC, as it reduced their efflux from skin explants and their migration in transwell cultures. These results suggest that Leishmania LPG impairs LC migration out of the skin and thus may modulate their immunostimulatory functions, which require LC translocation from skin to lymph nodes.

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Citations

Aug 30, 2003·Molecular and Biochemical Parasitology·Ingeborg BeckerArmando Isibasi
Oct 22, 2003·The Journal of Experimental Medicine·Gianluca RottaMaria Rescigno
Apr 11, 2003·Current Opinion in Infectious Diseases·Peter C Melby
Jul 20, 2010·Biochemistry. Biokhimii︠a︡·N M Novozhilova, N V Bovin
Apr 24, 2012·Journal of Parasitology Research·Luis H FrancoDario S Zamboni
Oct 22, 2008·International Journal for Parasitology·Angelika WagnerUrsula Wiedermann
Jan 20, 2005·European Journal of Immunology·Toni AebischerPaola Ricciardi-Castagnoli
Jul 17, 2003·Cellular Microbiology·Heidrun Moll
Dec 20, 2005·Cellular Immunology·Fenna C M SilléMarianne Boes
Dec 15, 2004·Microbes and Infection·Olga BrandonisioMaria Pepe
Oct 16, 2004·Immunobiology·Monidipa Ghosh, Santu Bandyopadhyay
May 26, 2004·Archives of Biochemistry and Biophysics·A Kwame NyameRichard D Cummings
Sep 17, 2005·Immunobiology·Esther CaparrósMaría Colmenares
Mar 6, 2010·Journal of Biomedicine & Biotechnology·César A TerrazasLorena Gómez-García
Oct 13, 2004·FEMS Immunology and Medical Microbiology·Julien DianaClaude Vincent
Sep 25, 2015·Microbiology and Immunology·Jesús Argueta-DonohuéLaila Gutiérrez-Kobeh
Dec 3, 2015·PLoS Neglected Tropical Diseases·Michelle A FavilaMary Ann McDowell
Sep 9, 2004·Journal of Separation Science·Nurten AksoyFatih Akcay
Oct 31, 2002·Nature Immunology·David Sacks, Alan Sher
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agnès BoitelleCatherine E Lawrence
Jun 6, 2018·Frontiers in Microbiology·María Martínez-LópezDavid Sancho
Mar 16, 2019·Frontiers in Immunology·Rafael TibúrcioCláudia Brodskyn
Oct 12, 2020·Cytokine·Chandan Raybarman, Surajit Bhattacharjee
Aug 17, 2021·Frontiers in Cellular and Infection Microbiology·Monrat Chulanetra, Wanpen Chaicumpa

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