Leishmania major: low infection dose causes short-lived hyperalgesia and cytokines upregulation in mice

Experimental Parasitology
Marc C KaramGeorge M Baroody

Abstract

Neural involvement was traditionally associated with leprosy. However, more recent studies have shown the presence of a persistent hyperalgesia in cutaneous leishmaniasis caused by the infection of BALB/c mice with a high dose of Leishmania major. In this study, we report the presence of hyperalgesia within the first two weeks of infection caused by a low dose of the parasite. Using BALB/c mice, we demonstrate the presence of hyperalgesia during the first 10 days of infection as assessed by thermal pain tests. After 10 days these decreased pain thresholds start to recover resulting in similar levels to those in uninfected controls during the third week of infection. This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection. In conclusion, this study shows that, during early infection, the low dose of L. major causes hyperalgesia accompanied by an upregulation of IL-1beta and IL-6 and that these effects are reversed within the first two weeks of infection.

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Citations

May 20, 2015·Current Opinion in Microbiology·Guillermo Arango Duque, Albert Descoteaux
Oct 24, 2014·Frontiers in Immunology·Guillermo Arango Duque, Albert Descoteaux
Mar 14, 2018·The Journal of Pharmacy and Pharmacology·Suelen S da SilvaIvete Conchon Costa
Jul 10, 2019·Journal of Internal Medicine·T CrossonS Talbot
Jul 27, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guillermo Arango DuqueAlbert Descoteaux
Dec 10, 2016·Parasitology Research·Sergio M BorghiWaldiceu A Verri
May 30, 2019·Journal of Neuroinflammation·Sergio M BorghiWaldiceu A Verri
May 4, 2021·Nitric Oxide : Biology and Chemistry·Fernanda V CabralMartha S Ribeiro

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