PMID: 8615459Apr 1, 1996Paper

Leishmania RNA viruses in Leishmania of the Viannia subgenus

The American Journal of Tropical Medicine and Hygiene
G SalinasN G Saravia

Abstract

Karyotype analysis of 69 strains of Leishmania belonging to three species of the Viannia subgenus originating from the southeastern and southwestern regions of Colombia revealed approximately 5.3-kb RNAs in four strains of L. braziliensis and also in the World Health Organization reference strain L. guyanensis IWHI/BR/78/M5313. The RNA element in this reference strain and in L. braziliensis strains isolated from cutaneous and mucosal lesions of four patients hybridized with RNA probes prepared from cDNA of the RNA virus present in L. guyanensis strain CUMC-1-1A (LRV1-1). These strains also contained an 80-kD protein that reacted with polyclonal antibody prepared against a recombinant fragment of the coat (capsid) protein of LRV1-1. In addition, another Colombian strain of L. braziliensis was found to contain an approximately 3.5-kb RNA that did not hybridize with LRV1-1 probes. Contrasting with the strains containing the 5.3-kb RNA, a total lysate of this strain did not contain material reactive with antiserum to the capsid protein fragment. All Leishmania containing LRV1-related viruses identified to date have originated in the Amazon River basin. Karyotype analyses and biological characterization of 17 clones obtained from th...Continue Reading

Citations

Feb 12, 2011·Science·Annette IvesSlavica Masina
Mar 10, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sebastian A Stifter, Carl G Feng
Nov 26, 2015·The American Journal of Tropical Medicine and Hygiene·Marine GinouvèsGhislaine Prévot
Sep 16, 2015·PLoS Neglected Tropical Diseases·Lilian Motta CantanhêdeRicardo de Godoi Mattos Ferreira
Feb 3, 2016·The American Journal of Tropical Medicine and Hygiene·Laurent ParmentierNicolas Fasel
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Matteo RossiNicolas Fasel
May 4, 2018·Pathogens and Disease·Arissa Felipe BorgesFátima Ribeiro-Dias
Apr 30, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Muhammed NalçacıSeray Töz
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Jul 19, 2016·Nature Reviews. Immunology·Phillip Scott, Fernanda O Novais
Nov 5, 2020·The American Journal of Tropical Medicine and Hygiene·Marcela Parra-MuñozMaría C Echeverry

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