Leishmania Vaccines Entered in Clinical Trials: A Review of Literature

International Journal of Preventive Medicine
Mohammad MoafiRoya Taleban

Abstract

Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity in most of the human cases, many bodies of research have been focusing on Leishmania vaccines, being capable to control Leishmania infection. First generation vaccines (such as Leishmune® and CaniLeish®) have proved robust protective immunity in dogs. In human, recombinant vaccines, including Leish-F1 could confer some degrees of protective immunity against natural infection. Recently, ChAd63-KH DNA vaccine has been accomplished in providing prevention against Leishmania infection; however, this vaccine should be further evaluated in other clinical trials.

References

Jul 21, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·J ConvitI Tomedes
Jun 17, 2009·Parasite Immunology·S A AliR C Rees
May 4, 2011·Memórias do Instituto Oswaldo Cruz·Márcia Cristina Aquino TeixeiraLain Carlos Pontes-de-Carvalho
Oct 23, 2013·Antimicrobial Agents and Chemotherapy·Ricardo ObonagaNancy Gore Saravia
May 8, 2014·Expert Review of Anti-infective Therapy·Manu VanaerschotJean-Claude Dujardin
Aug 1, 2014·Expert Opinion on Biological Therapy·Ali Khamesipour
Sep 10, 2014·Antimicrobial Agents and Chemotherapy·S ImbertA Fekkar
Jan 27, 2015·Veterinary Parasitology·Luigi Gradoni
Apr 11, 2015·Journal of Immunological Methods·Keerti Jain, N K Jain
Jul 16, 2015·Clinical & Translational Immunology·Rhea N ColerSteven G Reed
Mar 15, 2016·Vaccine·Portia M GillespieMaria Elena Bottazzi
Feb 9, 2017·Scandinavian Journal of Immunology·M MoafiN Ansari

❮ Previous
Next ❯

Citations

Jan 10, 2020·Expert Opinion on Drug Delivery·Anis AskarizadehAli Khamesipour
Jul 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhirong MouJude E Uzonna
Sep 25, 2020·PLoS Neglected Tropical Diseases·Peter J Hotez
Apr 5, 2020·Tropical Medicine and Infectious Disease·Thomas Holowka, Richard Bucala
Mar 27, 2020·Frontiers in Immunology·Clarisa Beatriz Palatnik-de-Sousa, Dirlei Nico
Nov 26, 2020·Cadernos de saúde pública·Expedito José de Albuquerque Luna, Sérgio Roberto de Souza Leão da Costa Campos
Dec 19, 2019·Microorganisms·Camila Dos Santos Meira, Lashitew Gedamu
Mar 23, 2021·Current Tropical Medicine Reports·Sarah MannJosé A Suarez
Apr 4, 2021·Pharmaceutics·Veronica FollieroMassimiliano Galdiero
Mar 31, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Brima M YounisAhmed M Musa
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Thalia Pacheco-FernandezHira L Nakhasi
Apr 8, 2021·Parasitology Research·Santanu Sasidharan, Prakash Saudagar
Apr 17, 2021·Journal of Nanobiotechnology·Humzah JamshaidGul Majid Khan
Apr 16, 2021·Immunotherapy·Camila Alves MotaThaís Gomes Verzignassi Silveira
Dec 2, 2020·Seminars in Immunology·Derek T O'HaganGiuseppe Lofano
May 4, 2021·Frontiers in Cell and Developmental Biology·Marcelo Santos da Silva
May 4, 2021·Frontiers in Veterinary Science·Virginia AidaConstantinos S Kyriakis
May 14, 2021·PLoS Neglected Tropical Diseases·Adriano Casulli
Jul 29, 2021·Future Microbiology·Tarun MathurAshwani K Verma
Aug 9, 2021·Trends in Parasitology·Samuel Cota TeixeiraVeridiana de Melo Rodrigues

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Immunological Methods
Keerti Jain, N K Jain
Voenno-medit︠s︡inskiĭ zhurnal
A I Fedorov
Acta Tropica
Maria Vang JohansenNorbert W Brattig
© 2021 Meta ULC. All rights reserved