Leishmaniasis immunopathology-impact on design and use of vaccines, diagnostics and drugs.

Seminars in Immunopathology
Paul M KayeSimon L Croft

Abstract

Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis (VL) and cutaneous or tegumentary leishmaniasis (CL), as well as several other cutaneous manifestations in a minority of cases. In the mammalian host Leishmania parasites infect different populations of macrophages where they multiply and survive in the phagolysosomal compartment. The progression of both VL and CL depends on the maintenance of a parasite-specific immunosuppressive state based around this host macrophage infection. The complexity and variation of immune responses and immunopathology in humans and the different host interactions of the different Leishmania species has an impact upon the effectiveness of vaccines, diagnostics and drugs.

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Citations

Aug 1, 2020·Parasite Immunology·Srija MoulikMitali Chatterjee
Jun 20, 2020·Seminars in Immunopathology·Marcel Tanner
Nov 1, 2020·International Journal of Molecular Sciences·Catalina Avendaño, Manuel Alfonso Patarroyo
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Thalia Pacheco-FernandezHira L Nakhasi
Jul 21, 2021·International Journal of Molecular Sciences·Génesis PalaciosEmma Carmelo
Oct 19, 2021·Frontiers in Cellular and Infection Microbiology·Fernanda Tomiotto-PellissierWander Rogério Pavanelli
Nov 4, 2021·Expert Review of Vaccines·Paul M KayeStefano Malvolti

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Methods Mentioned

BETA
biopsy
biopsies
ELISA

Clinical Trials Mentioned

NCT04107961
NCT01437020

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