Leishmaniasis recidivans by Leishmania tropica in Central Rift Valley Region in Kenya

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Joseph Wambugu GitariMatilu Mwau

Abstract

This study sought to determine the endemic Leishmania species, the clinical features of cutaneous leishmaniasis (CL) in the Central Rift Valley in Kenya and to give an account on unresponsiveness to treatment in the region. Participants were clinically identified and grouped into untreated, classical and recidivate based on clinical manifestation and clinical data. Leishmaniasis recidivans lesions were scaly hyperemic papules that appeared before the classic lesion had healed or after healing. The demographics and socio-economic data were recorded and lesion scraping samples screened through microscopy and Internal Transcribed Spacer 1-PCR. Leishmania species were identified using Restriction Fragment Length Polymorphism. A total of 52 participants were sampled, of which, 44.2% of the cases were recidivate and L. tropica the only species identified. All patients had been treated using sodium stibogluconate (SSG) which is the recommended first-line drug in Kenya. 60% of the patients experienced prolonged exposure to the drug (>30 days). L. tropica is the endemic Leishmania species for CL leading to classical and leishmaniasis recidivans. Treatment of CL in the area is not effective hence, alternative measures/therapy should be c...Continue Reading

Citations

Jun 13, 2019·PLoS Neglected Tropical Diseases·Mohammad Reza AflatoonianRajender S Varma
Nov 20, 2019·Parasite Immunology·Angélica P Isaac-Márquez, Claudio M Lezama-Dávila
Oct 7, 2020·Pathogens·Ahyun HongMaria Fernanda Laranjeira-Silva
Mar 3, 2021·Actas dermo-sifiliográficas·I Abadías-GranadoY Gilaberte
May 29, 2021·Actas dermo-sifiliográficas·I Abadías-GranadoY Gilaberte
Sep 4, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Omar AmahmidDriss Belghyti

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