Leishmanicidal Activity and Structure-Activity Relationships of Essential Oil Constituents

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Audrey R S T SilvaSilvio S Dolabella

Abstract

Several constituents of essential oils have been shown to be active against pathogens such as bacteria, fungi, and protozoa. This study demonstrated the in vitro action of ten compounds present in essential oils against Leishmania amazonensis promastigotes. With the exception of p-cymene, all evaluated compounds presented leishmanicidal activity, exhibiting IC50 between 25.4 and 568.1 μg mL-1. Compounds with the best leishmanicidal activity presented a phenolic moiety (IC50 between 25.4 and 82.9 μg mL-1). Alicyclic alcohols ((-)-menthol and isoborneol) and ketones ((-)-carvone) promoted similar activity against the parasite (IC50 between 190.2 and 198.9 μg mL-1). Most of the compounds showed low cytotoxicity in L929 fibroblasts. Analysis of the structure-activity relationship of these compounds showed the importance of the phenolic structure for the biological action against the promastigote forms of the parasite.

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Citations

Mar 19, 2019·Oxidative Medicine and Cellular Longevity·Emanuela Coutinho LunaFrancisco Jaime Bezerra Mendonça
Dec 4, 2020·The Journal of Veterinary Medical Science·Sara T ElazabYoshifumi Nishikawa
May 23, 2020·Journal of Ethnopharmacology·Raissa Couto SantanaLucia H Pinto-da-Silva
Jan 29, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nelson Siukei LamFangli Lu

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