Leishmanicidal activity of phenylene bridged C2 symmetric glycosyl ureides

Bioorganic & Medicinal Chemistry Letters
Neetu TewariSuman Gupta

Abstract

A number of phenylene bridged C2 symmetric glycosyl uerides with ester (3a-f), alcohol (4a-c) and acid (5a-d) functionalities were prepared by addition of glycosyl amino esters with phenyl diisocyanates and their further reaction with LiAlH(4) or hydrolysis with LiOH. All the compounds were screened for their in vitro and in vivo antileishmanial activity. Most of the compounds exhibited good activity while two of the compounds 3e and 3f reduced the clinical dose of standard drug SSG.

References

Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J L AvilaR K Robins
Oct 1, 1988·Trends in Pharmacological Sciences·S L Croft
Mar 1, 1987·The American Journal of Tropical Medicine and Hygiene·M RabinovitchM Pouchelet
Sep 1, 1984·Journal of Medicinal Chemistry·H B CottamG R Revankar
Mar 1, 1996·Trends in Biochemical Sciences·M D Jacobson
Apr 4, 1998·Antimicrobial Agents and Chemotherapy·J W BenbowJ R Mead
Jun 12, 1999·Planta medica·O KayserH Kolodziej
Jun 17, 2000·International Journal for Parasitology·E CauchetierM Deniau
May 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M el-Hassan, E E Zijlstra
Feb 15, 2002·Bioorganic & Medicinal Chemistry Letters·Esther del OlmoArturo San Feliciano
Sep 28, 2002·European Journal of Medicinal Chemistry·R P TripathiB S Srivastava
Jun 5, 2003·Emerging Infectious Diseases·Richard ReithingerPaul G Coleman
Oct 29, 2003·Trends in Parasitology·Simon L Croft, Graham H Coombs

❮ Previous
Next ❯

Citations

Dec 20, 2005·Nucleic Acids Research·Sandeep Kumar SrivastavaRavishankar Ramachandran
Dec 15, 2007·Medicinal Research Reviews·Namrata DwivediRama Pati Tripathi
Dec 25, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Halison Correa GoliasJoão Alencar Pamphile
Sep 26, 2014·Chemical Reviews·Hidayat HussainSimon Gibbons

❮ Previous
Next ❯