Leishsmania (Leishmania) amazonensis infection: Muscular involvement in BALB/c and C3H.HeN mice

Experimental Parasitology
Mariana Silva-AlmeidaKátia S Calabrese

Abstract

Recent studies have provided some insights into Leishsmania (Leishmania) amazonensis muscular infection in dogs, although, muscular disease due to leishmaniasis has been poorly documented. The aim of our study was to evaluate involvement of Leishmania in muscular infection of two distinct mouse strains (BALB/c and C3H.He), with different genetic backgrounds. BALB/c mice, susceptible to Leishmania infection, showed, at the beginning of infection, a great number of infected macrophages among muscle fibers; however, in C3H.He resistant mice, muscle fibers were less damaged than in BALB/c mice, but some parasitized macrophages could be seen among them. A follow up of the infection showed an intense inflammatory infiltrate mainly composed of infected macrophages in BALB/c muscles and the presence of amastigotes within muscle fibers; while C3H.He mice exhibited a moderate inflammatory infiltrate among skeletal muscle fibers and an absence of amastigotes. Total destruction of muscles was observed in BALB/c mice in the late phase of infection (day 90) while C3H.He mice showed a process of muscle repair. We concluded that: (1) the muscles of BALB/c mice were more affected by leishmaniasis than those of C3/H.He mice; (2) Leishmania amast...Continue Reading

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Citations

Sep 2, 2011·Parasitology Research·Samar N El-BeshbishiGoman A El-Ganainy
Feb 8, 2013·The American Journal of Tropical Medicine and Hygiene·Max GroglRichard J Sciotti
Apr 21, 2012·Journal of Parasitology Research·Joao Luiz Mendes WanderleyMarcello Barcinski
Nov 4, 2016·Malaria Journal·Mauro Toledo Marrelli, Marco Brotto

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