Lenalidomide down regulates the production of interferon-gamma and the expression of inhibitory cytotoxic receptors of human Natural Killer cells

Cellular Immunology
Nicolas DauguetMary Poupot

Abstract

Lenalidomide, a daughter molecule of Thalidomide, and IMIDs are immunomodulatory drugs that have been described as having immunomodulatory properties and anti-tumor activity. The effect of Lenalidomide towards Peripheral Blood Mononuclear Cells (PBMC) has been studied and direct effects towards T cells have been described, such as an increase of interferon-gamma (IFN-gamma) and interleukin (IL)-2 production. As a consequence, it has been also described that IL-2 subsequently activates Natural Killer (NK) cells. Nevertheless, direct effects of Lenalidomide on NK cells from healthy volunteers have never been described, if searched. Here we show that Lenalidomide can inhibit the production of IFN-gamma by NK cells from healthy donors. It also modifies the phenotype of NK cells through a decrease of the expression of Killer cell Immunoglobulin-like Receptors (KIRs) and NKp46. However, we did not detect consequence of these phenotype modifications on the cytotoxic potential of NK cells.

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Citations

Mar 17, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shancheng RenYinghao Sun
Jul 14, 2011·Investigational New Drugs·Martin Schmidt-HieberIgor Wolfgang Blau
Jan 12, 2012·Journal of Chemotherapy·V Kumar, S Chhibber
Apr 2, 2020·Cancers·Kanako ShimizuAnd Shin-Ichiro Fujii
Feb 2, 2021·Pigment Cell & Melanoma Research·Naveed PervaizRavinder Kumar
Jul 14, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Sandra DomingoJosefina Cortés-Hernández

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