Lenalidomide in combination with R-CHOP (R2-CHOP) as first-line treatment of patients with high tumour burden follicular lymphoma: a single-arm, open-label, phase 2 study

The Lancet. Haematology
Hervé TillyLymphoma Study Association

Abstract

Immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is a standard front-line treatment for follicular lymphoma. The combination of lenalidomide and rituximab has shown high efficacy in relapsed or refractory and untreated follicular lymphoma. We aimed to evaluate the safety and activity of the combination of lenalidomide and R-CHOP (R2-CHOP) in previously untreated patients with high burden follicular lymphoma. This single-arm, open-label, multicentre, phase 2 trial was done in 16 hospitals in France, all of which were Lymphoma Study Association (LYSA) sites. Eligible patients were aged 18-70 years and had previously untreated CD20-positive follicular lymphoma of grade 1, 2, or 3a; at least one high tumour burden criterion according to Groupe d'Etude des Lymphomes Folliculaires criteria; an Eastern Cooperative Oncology Group performance status score of 2 or less; and a minimum life expectancy of more than 3 months. Patients received induction therapy with six cycles of R2-CHOP every 3 weeks (one cycle involved standard R-CHOP on days 1-5, and 25 mg oral lenalidomide per day on days 1-14), followed by two rituximab infusions at 3-week intervals. The total treatment schedule was ...Continue Reading

Citations

Jun 25, 2020·British Journal of Haematology·Christopher McNamaraPam McKay
May 18, 2019·American Society of Clinical Oncology Educational Book·Mark Roschewski, Brian T Hill
Feb 6, 2020·British Journal of Haematology·Thomas MenterStefan Dirnhofer
Jul 16, 2019·Current Hematologic Malignancy Reports·Samuel Yamshon, Jia Ruan
Jan 15, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lucie ObericFabrice Jardin
Feb 23, 2021·Drugs·Michael Northend, William Townsend
Aug 28, 2021·International Journal of Molecular Sciences·Nikolaos IoannouAlan G Ramsay

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