Lenalidomide Synergistically Enhances the Effect of Dendritic Cell Vaccination in a Model of Murine Multiple Myeloma

Journal of Immunotherapy
Thanh-Nhan Nguyen-PhamJe-Jung Lee

Abstract

We investigated the efficacy of lenalidomide (LEN) in combination with dendritic cell (DC) vaccination in the MOPC-315 murine myeloma model. After tumor growth, LEN was injected intraperitoneally for 4 consecutive days in combination with DC vaccination. The combination of LEN and vaccination efficiently inhibited tumor growth compared with the single agents alone. A cytotoxic assay revealed that the anticancer effects of DC vaccination plus LEN involved not only generation of antigen-specific cytotoxic T lymphocytes but also NK cells. Vaccinated mice had reduced numbers of suppressor cells, including both myeloid-derived suppressor cells and regulatory T cells, in the spleen. The proportions of CD4+ and CD8+ T cells increased in the spleen, and a Th1 cytokine (interferon-γ) rather than a Th2 cytokine (interleukin-10) was synthesized in response to tumor antigens. LEN enhanced the innate immune response by modulating NK cell numbers and function. In addition, LEN reduced the production levels of angiogenesis-inducing factors in tumor-bearing mice. Together, these results suggest that a combination of LEN and DC vaccination may synergistically enhance anticancer immunity in the murine myeloma model, by inhibiting immunosuppresso...Continue Reading

References

Apr 30, 2010·Current Drug Targets·Gang Niu, Xiaoyuan Chen
Apr 2, 2014·Leukemia & Lymphoma·Shaji K Kumar, Morie A Gertz

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Citations

Mar 24, 2018·European Journal of Haematology·Marzia PalmaHåkan Mellstedt
Oct 13, 2015·Blood Research·Hyun-Ju LeeJe-Jung Lee
May 24, 2018·Cardiovascular & Hematological Disorders Drug Targets·Ota Fuchs
Feb 14, 2019·The Korean Journal of Internal Medicine·Manh-Cuong VoJe-Jung Lee
Oct 18, 2019·Cancer Immunology, Immunotherapy : CII·Caterina LapentaStefano M Santini
May 17, 2019·Journal of Oncology·Rachel E CookeDavid Ritchie
Apr 24, 2020·Cancer Immunology, Immunotherapy : CII·Maria Christina CoxStefano M Santini
Mar 29, 2018·Nature Communications·Urszula CytlakVenetia Bigley
Aug 21, 2018·Frontiers in Immunology·Manh-Cuong VoJe-Jung Lee
Feb 6, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shaji K Kumar, Kenneth C Anderson

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Methods Mentioned

BETA
flow cytometry
ELISA

Clinical Trials Mentioned

NCT00698776

Software Mentioned

SPSS
WinMDI

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