Length but not transverse diameter of the excision specimen for high-grade cervical intraepithelial neoplasia (CIN 2-3) is a predictor of pregnancy outcome

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Carlo Antonio LiveraniAndrea Ciavattini

Abstract

The objective of this study was to analyze the impact of cone characteristics (depth, transverse diameter, and volume) on subsequent pregnancies after the loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN 2-3). Pregnancy outcomes (preterm birth, gestational age at birth, mode of delivery, and birth weight) of 501 women with singleton gestations and no previous preterm birth or history of late miscarriage, who had previously undergone a single LEEP for CIN 2-3, were retrospectively analyzed with respect to length, transverse diameter, and volume of the excision specimen. The overall incidence of preterm birth was 2.4%. The rate of preterm birth in women with length greater than 20 mm or volume greater than 2.5 cm was significantly higher than that in women with length between 15 and 19 mm (15.6 vs. 3.9%, P=0.02) or women with volume between 2.0 and 2.4 cm (5.8 vs. 1.6%, P=0.04). A linear inverse correlation (r=-0.3, P<0.001) between gestational age at birth and length, but not volume (r=0.0, P=0.9) or transverse diameter (r=0.2, P<0.0001), emerged. The mode of delivery was not affected by cone characteristics. Length, but not transverse diameter and volume, of the excised specimen seems t...Continue Reading

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Citations

Dec 23, 2017·Journal of Lower Genital Tract Disease·Stephanie A SullivanLisa Rahangdale
Sep 28, 2017·Journal of Lower Genital Tract Disease·Andrea CiavattiniUNKNOWN Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV).
Nov 3, 2017·The Cochrane Database of Systematic Reviews·Maria KyrgiouEvangelos Paraskevaidis
Feb 20, 2019·Archives of Pathology & Laboratory Medicine·Francesco SopracordevoleAndrea Ciavattini
Feb 2, 2019·Journal of Lower Genital Tract Disease·Andrea CiavattiniFrancesco Sopracordevole
Feb 27, 2020·Journal of Clinical Laboratory Analysis·Haizhen HeLiqin Cao
Jan 10, 2019·Oxidative Medicine and Cellular Longevity·Monia OrcianiAndrea Ciavattini
Apr 1, 2018·Archives of Gynecology and Obstetrics·Eliana MontanariHeinrich Husslein
Dec 8, 2019·Archives of Gynecology and Obstetrics·Carla E SchulmeyerMartin C Koch

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