Jul 28, 2015

Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference

BioRxiv : the Preprint Server for Biology
Xumin NiShuhua Xu

Abstract

As a chromosome is sliced into pieces by recombination after entering an admixed population, ancestral tracks of chromosomes are shortened with the pasting of generations. The length distribution of ancestral tracks reflects information of recombination and thus can be used to infer the histories of admixed populations. Previous studies have shown that inference based on ancestral tracks is powerful in recovering the histories of admixed populations. However, population histories are always complex, and previous studies only deduced the length distribution of ancestral tracks under very simple admixture models. The deduction of length distribution of ancestral tracks under a more general model will greatly elevate the power in inferring population histories. Here we first deduced the length distribution of ancestral tracks under a general model in an admixed population, and proposed general principles in parameter estimation and model selection with the length distribution. Next, we focused on studying the length distribution of ancestral tracks and its applications under three typical admixture models, which were all special cases of our general model. Extensive simulations showed that the length distribution of ancestral trac...Continue Reading

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Mentioned in this Paper

Study
Theoretical Model
Recombination, Genetic
Mexican
African American
South
Chromosomes
Simulation
Asians
Silo (Dataset)

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