Feb 1, 1988

Length of excitation wave and susceptibility to reentrant atrial arrhythmias in normal conscious dogs

Circulation Research
P L RensmaM J Schalij


We calculated the wavelength of the atrial impulse in chronically instrumented conscious dogs by measuring both conduction velocity and refractory period: wavelength = refractory period X conduction velocity. Implantation of multiple stimulating and recording electrodes allowed wavelength determination at four different areas: the right and left parts of Bachmann's bundle and the free walls of the right and left atria. During programmed electrical stimulation, three types of arrhythmias were observed: rapid repetitive responses, atrial flutter, and atrial fibrillation. During normal rhythm, the wavelength of the atrial impulse varied between 14 and 18 cm. Premature beats had a shorter wavelength, depending on the degree of prematurity. Premature beats that evoked rapid repetitive responses showed a critical shortening of the wavelength below 12.3 cm. Episodes of atrial flutter were induced at a wavelength below 9.7 cm, while fibrillation occurred at wavelengths shorter than 7.8 cm. We correlated the induction of these arrhythmias with the values of refractory period, conduction velocity, and wavelength during control and during administration of several drugs. Intravenous administration of acetylcholine shortened the wavelength...Continue Reading

  • References24
  • Citations284


  • References24
  • Citations284


Mentioned in this Paper

Anti-Arrhythmia Agents
Blastocyst Implantation, Natural
Refractory Period, Electrophysiological
Nerve Conduction Function
Atrial Fibrillation
Refractory Period

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