Length of intravenous antibiotic therapy and treatment failure in infants with urinary tract infections.

Pediatrics
Patrick W BradyAnthony Goudie

Abstract

The goal was to determine the association between short-duration (< or =3 days) and long-duration (> or =4 days) intravenous antibiotic therapy and treatment failure in a cohort of young infants hospitalized with urinary tract infections (UTIs). We conducted a retrospective cohort study of infants <6 months of age who were hospitalized with UTIs between 1999 and 2004 at 24 children's hospitals in the Pediatric Health Information System. Our main model adjusted for all covariates, propensity scores, and clustering according to hospital to evaluate the effect of short versus long courses of inpatient intravenous antibiotic therapy on treatment failure, defined as readmission because of UTI within 30 days. Of the 12,333 infants who met the inclusion criteria, 240 (1.9%) experienced treatment failure. The treatment failure rates were 1.6% for children who received short-course intravenous antibiotic treatment and 2.2% for children who received long-course treatment. Treatment courses varied substantially across hospitals and with patient-level characteristics. After multivariate adjustment, including propensity scores, there was no significant association between treatment group and outcomes, with an odds ratio for long versus shor...Continue Reading

Citations

Mar 7, 2012·European Journal of Clinical Pharmacology·Matthew S DaviesW Stephen Waring
Nov 26, 2010·The Pediatric Infectious Disease Journal·Walter ZinggDidier Pittet
Dec 31, 2010·Current Opinion in Pediatrics·Mashael Alqahtani, Deepa Mukundan
Jan 10, 2012·Current Opinion in Pediatrics·Rolf Beetz
Dec 18, 2010·European Journal of Medical Research·Michael H Wilke
Mar 14, 2012·Pediatrics·Michael R StengerWilliam Gardner
Mar 4, 2014·Hospital Pediatrics·Alan R Schroeder
May 20, 2014·The Pediatric Infectious Disease Journal·Diana AverbuchDan Engelhard
Dec 4, 2012·Expert Review of Anti-infective Therapy·Maria Bitsori, Emmanouil Galanakis
Jul 14, 2012·Advances in Pediatrics·Ian M Paul
Nov 4, 2015·Hospital Pediatrics·Geetika KumarEyal Cohen
Nov 30, 2011·Acta Paediatrica·Anita AmmentiUNKNOWN Italian Society of Pediatric Nephrology
Jul 27, 2012·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Karen E JerardiJoel S Tieder
Jul 22, 2014·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Alan R Schroeder, Shawn L Ralston
Sep 17, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Siiri KõljalgMarika Mikelsaar
Oct 16, 2014·Hospital Pediatrics·Janet A McMullenPatricia C Parkin
Jan 3, 2015·Hospital Pediatrics·Heidi K RomanAlan R Schroeder
Dec 6, 2014·European Urology·Raimund SteinSerdar Tekgül
Jul 17, 2015·Archives of Disease in Childhood·Alan R SchroederTara L Greenhow
Jul 5, 2018·Journal of Paediatrics and Child Health·David Isaacs
Jun 26, 2013·Antimicrobial Agents and Chemotherapy·Hayden T SchwenkThomas J Sandora
Sep 15, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Jun WangYunfei Guo
Mar 3, 2020·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Pearl W ChangAlan R Schroeder
May 28, 2019·Pilot and Feasibility Studies·Irit R RasoolyUNKNOWN Pediatric Research in Inpatient Settings (PRIS) Network
Aug 21, 2020·Hospital Pediatrics·Neha S Joshi, Marie E Wang
Aug 21, 2020·Hospital Pediatrics·Sheila SwartzPeter Havens
Aug 21, 2020·Hospital Pediatrics·Melanie C MarshCara Haberman
Dec 16, 2017·Hospital Pediatrics·Ariana M Witkin, Corrie E McDaniel
Mar 20, 2019·Hospital Pediatrics·Jessica L Markham, Jennifer L Goldman
Dec 3, 2017·Hospital Pediatrics·Neha S JoshiAlan R Schroeder
Jun 9, 2019·Hospital Pediatrics·Jared P Austin, Byron A Foster
Aug 28, 2019·Acta Paediatrica·Anita AmmentiUNKNOWN Italian Society of Pediatric Nephrology
Jul 6, 2020·European Journal of Pediatrics·Michael BuettcherThomas J Neuhaus
Feb 18, 2021·Journal of the Pediatric Infectious Diseases Society·Marie E WangAlan R Schroeder
Aug 28, 2021·Hospital Pediatrics·Nassr NamaUNKNOWN INSIGHTSCOPE TEAM
Sep 4, 2021·Journal of Infection and Public Health·Yasser M KazzazPatricia S Fontela
Jun 10, 2011·Current Opinion in Urology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Jonathan C CraigPrevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT) Inv
© 2021 Meta ULC. All rights reserved