Lenograstim. A review of its pharmacological properties and therapeutic efficacy in neutropenia and related clinical settings

Drugs
J E FramptonK L Goa

Abstract

Lenograstim is a recombinant glycosylated human granulocyte colony-stimulating factor (rHuG-CSF) which principally regulates the formation and function of neutrophils. Like other colony-stimulating factors (CSFs), lenograstim has been developed for the prevention and treatment of iatrogenic and disease-related neutropenic conditions. In phase III clinical studies, prophylactic administration of lenograstim shortened the duration of chemotherapy-induced neutropenia in patients with nonmyelogenous cancers who received standard-dose chemotherapy or myeloablative regimens followed by bone marrow transplantation (BMT). A decrease in the incidence of infection after standard regimens and fewer days with infectious and febrile neutropenic episodes during recovery from BMT occurred concomitantly with the amelioration of neutropenia. In each setting, the decrease in morbidity was associated with shorter hospitalisation times and reduced administration of parenteral antibacterial agents. As with another rHuG-CSF, filgrastim, bone pain (non-serious) was the most common adverse reaction to lenograstim therapy. This occurred in 13% of lenograstim recipients and 5% of placebo recipients treated for chemotherapy-induced neutropenia with stand...Continue Reading

Citations

Jun 1, 1996·Pharmacy World & Science : PWS·P Vermeij, D Blok
Aug 1, 2012·Theoretical Biology & Medical Modelling·Markus ScholzMarkus Loeffler
Dec 11, 2002·British Journal of Haematology·Eliane GluckmanUNKNOWN European Group for Blood and Marrow Transplantation Working Party for Severe Aplastic Anemia
Jun 3, 2014·Theoretical Biology & Medical Modelling·Sibylle SchirmMarkus Scholz
Oct 17, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cosmin I Ciotu, Michael J M Fischer

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