Lens autofluorescence is increased in newly diagnosed patients with NIDDM

Diabetologia
P Koefoed TheilH Lund-Andersen

Abstract

Lens and cornea autofluorescence has been shown to be increased in patients with insulin-dependent diabetes mellitus and to be positively correlated to glycaemic control and duration of diabetes. We have studied lens and cornea autofluorescence at the clinical onset of non-insulin-dependent diabetes mellitus (NIDDM), in comparison with age-matched subjects with normal glucose tolerance. Fourteen subjects with NIDDM diagnosed less than 6 months prior to the examination were characterised by ocular fluorometry, glycosylated hemoglobin A1c, plasma lipid status, arterial blood pressure, and an oral glucose tolerance test (OGTT). Eleven age- and gender-matched healthy subjects without a family history of diabetes and with a normal glucose tolerance underwent the same examinations. In 11 of the 14 diabetic patients lens autofluorescence was increased to levels higher than the age-related mean + 2SD of healthy subjects. For the entire study population, control and diabetic subjects, lens fluorescence was positively correlated with HbA1c (p < 0.0001, r = 0.73), fasting plasma glucose (p = 0.002, r = 0.60) and the plasma glucose level 2 h after an OGTT (p = 0.004, r = 0.55). Cornea autofluorescence was also significantly increased in th...Continue Reading

Citations

Aug 20, 2004·The British Journal of Ophthalmology·L KesselM Larsen
Oct 23, 2002·Acta Ophthalmologica Scandinavica·Bernhard M EgeToke Bek
Mar 22, 2002·Acta Ophthalmologica Scandinavica·Per FlesnerHenrik Lund-Andersen
Jul 23, 2005·Annals of the New York Academy of Sciences·Robbert MeerwaldtAndries Smit
Jul 23, 2005·Annals of the New York Academy of Sciences·Vincent M MonnierSaul Genuth
Sep 27, 2003·Acta Ophthalmologica Scandinavica·Line KesselMichael Larsen
Nov 5, 1999·Experimental Eye Research·H J Van SchaikJ A Van Best
May 31, 2014·Journal of Diabetes Science and Technology·Alin Stirban
May 31, 2014·Journal of Diabetes Science and Technology·Frederick CahnShardendu Mishra
Aug 6, 2013·Journal of Diabetes Science and Technology·Alin Stirban

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