Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition

Developmental Biology
Maria MuccioliTimothy F Plageman

Abstract

Development of the ocular lens commences with the formation of the lens placode, an epithelial structure that thickens and subsequently bends inward in a process called invagination. Invagination is observed during the development of many embryonic structures, but the spectrum of morphogenetic events driving this process are, in most cases, not fully understood. A characteristic commonly found in embryonic tissues undergoing epithelial reorganization is planar polarity, a property where cells are geometrically and/or molecularly orientated in a specific direction along the plane of an epithelium. Planar polarity is known to drive the morphogenesis of several epithelial structures, however its role during invagination events is less clear. We have found that at the onset of invagination, cells of the lens placode become geometrically planar polarized such that they are orientated toward a central point in the lens placode. Further investigation revealed that this is due to contraction of radially orientated junctions and the elongation of those circumferentially orientated. Radial junctions have an elevated localization of actomyosin and their contraction is dependent on the F-actin and Rho-kinase binding protein, Shroom3. Elong...Continue Reading

References

Mar 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R HendrixR Johnson
Mar 23, 2002·Science·Kathleen M Scully, Michael G Rosenfeld
Mar 20, 2004·Developmental Cell·Jennifer A Zallen, Eric Wieschaus
Sep 14, 2004·Science·Perihan NalbantKlaus M Hahn
Feb 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yanshu WangJeremy Nathans
Oct 3, 2006·Developmental Cell·J Todd BlankenshipJennifer A Zallen
Oct 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lei ChenYi Zheng
Mar 27, 2007·Developmental Biology·David P WelchmanJulie Ahringer
Feb 14, 2008·Journal of Cell Science·Flavia A WaldPedro J I Salas
Feb 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elena TorbanPhilippe Gros
Oct 7, 2009·The Journal of Cell Biology·Stephen J Warner, Gregory D Longmore
Nov 3, 2009·Developmental Cell·Rodrigo Fernandez-GonzalezJennifer A Zallen
Dec 23, 2009·Molecular and Cellular Endocrinology·Henrik Fagman, Mikael Nilsson
Sep 14, 2010·Developmental Cell·Sérgio de Matos SimõesJennifer A Zallen
May 5, 2011·Developmental Biology·Jie HuangDavid C Beebe
Aug 22, 2012·Annual Review of Cell and Developmental Biology·John B Wallingford
Oct 11, 2012·Development·Masazumi Tada, Carl-Philipp Heisenberg
Jan 3, 2013·Development, Growth & Differentiation·Vijay K Jidigam, Lena Gunhaga
Feb 19, 2014·The Journal of Cell Biology·Sérgio de Matos SimõesJennifer A Zallen
Jun 26, 2014·Development·Molly J HardingAlex Nechiporuk
Aug 17, 2014·Disease Models & Mechanisms·Jennifer N MurdochAndrew J Copp
Nov 5, 2014·Nature·Adam C ParéJennifer A Zallen
Jan 20, 2015·Nanotechnology·XiaoYi LiuHengAn Wu
Feb 26, 2015·Frontiers in Pharmacology·Xiaorei Sai, Raj K Ladher
Dec 2, 2015·Biology Open·Vijay K JidigamLena Gunhaga

❮ Previous
Next ❯

Citations

Mar 15, 2016·Experimental Eye Research·Catherine ChengVelia M Fowler
Apr 24, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicholas J HanoviceJeffrey M Gross
Mar 3, 2020·Developmental Biology·Nathalie S HoussinTimothy F Plageman
Jun 2, 2021·Seminars in Cell & Developmental Biology·Yu-Chiun Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.