Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling

Experimental Eye Research
Paul W HamiltonJ J Henry

Abstract

The frog, Xenopus laevis, possesses a high capacity to regenerate various larval tissues, including the lens, which is capable of complete regeneration from the cornea epithelium. However, the molecular signaling mechanisms of cornea-lens regeneration are not fully understood. Previous work has implicated the involvement of the Wnt signaling pathway, but molecular studies have been very limited. Iris-derived lens regeneration in the newt (Wolffian lens regeneration) has shown a necessity for active Wnt signaling in order to regenerate a new lens. Here we provide evidence that the Wnt signaling pathway plays a different role in the context of cornea-lens regeneration in Xenopus. We examined the expression of frizzled receptors and wnt ligands in the frog cornea epithelium. Numerous frizzled receptors (fzd1, fzd2, fzd3, fzd4, fzd6, fzd7, fzd8, and fzd10) and wnt ligands (wnt2b.a, wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway. When compared to flank epithelium, which is lens regeneration incompetent, only wnt11 and wnt11b are different (present only in the cornea...Continue Reading

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Citations

Aug 30, 2016·Experimental Eye Research·Paul W Hamilton, Jonathan J Henry
Mar 27, 2018·Molecular Biology and Evolution·Jonathan J Henry, Paul W Hamilton
Nov 2, 2019·Current Eye Research·Bharat Kumar, M A Reilly
Oct 28, 2020·International Journal of Molecular Sciences·Kasem TheerakittayakornRangsun Parnpai
Jan 23, 2018·Experimental Eye Research·Cindy X KhaKelly Ai-Sun Tseng
Apr 15, 2019·Experimental Eye Research·Surabhi SonamJonathan J Henry
Jul 6, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Wenqing LiuJinlian Hua

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