PMID: 6112745Mar 1, 1981Paper

Lens transglutaminase and cataract formation

Proceedings of the National Academy of Sciences of the United States of America
L LorandN S Rafferty

Abstract

A protein polymer characteristically present in human cataract was shown to contain significant amounts of gamma-glutamyl-epsilon-lysine isopeptides. It is proposed that these crosslinks are produced by the action of transglutaminase (R-glutaminyl-peptide:amine-gamma-glutamyl-yltransferase, EC 2.3.2.13), which is all the more plausible because lens contains the enzyme and endogenous protein substrates for it. The enzyme is similar to that obtained from liver and is Ca2+ dependent. Highest apparent activity is found in lens cortex. When cortex homogenate from the rabbit was incubated in the presence of Ca2+ with either [14C]putrescine or with dansylcadaverine, a a selective incorporation of the radioactive or fluorescent amine into the heavier subunits (Mr approximately 26,000 and 30,000) of beta-crystallins could be demonstrated. Possible modes of regulating the crosslinking activity of this enzyme in lens are discussed.

References

Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L LorandJ Bruner-Lorand
Dec 21, 1977·Biochemical and Biophysical Research Communications·H G Williams-AshmanL Lorand
Mar 1, 1979·Analytical Biochemistry·L LorandA J Gray
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V J StevensA Cerami
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A Spector, D Roy
Feb 1, 1979·Experimental Eye Research·P P Fagerholm
Dec 1, 1978·Experimental Eye Research·J A KrampsJ Wollensak
Jul 8, 1977·Science·H Bloemendal
Dec 8, 1972·Annals of the New York Academy of Sciences·L LorandA Gray
Dec 8, 1972·Annals of the New York Academy of Sciences·L Lorand
Dec 1, 1972·Analytical Biochemistry·L LorandL Cooperstein
Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·L Lorand, D Chenoweth
Apr 19, 1968·Biochemical and Biophysical Research Communications·L LorandS Tokura
Mar 1, 1968·Biochemistry·L LorandJ Bruner-Lorand

❮ Previous
Next ❯

Citations

Feb 1, 1993·Protein Science : a Publication of the Protein Society·L R MiesbauerD L Smith
Jan 1, 1984·Molecular and Cellular Biochemistry·L Lorand, S M Conrad
Jan 1, 1984·Molecular and Cellular Biochemistry·M Griffin, J Wilson
Jul 30, 2011·Amino Acids·Claudio TabolacciSimone Beninati
Dec 1, 1985·Experimental Eye Research·M J Crabbe
Jan 1, 1984·The International Journal of Biochemistry·M A Grillo, D C Pezzali
Sep 1, 1995·Phytochemistry·D Serafini-FracassiniS Beninati
Jun 2, 1983·Biochimica Et Biophysica Acta·A M BerstenJ A Lucy
Jan 1, 1983·Progress in Neurobiology·E Kvamme
Dec 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D HandL W Haynes
Dec 1, 1995·The International Journal of Biochemistry & Cell Biology·R N SinghK Mehta
Dec 12, 2001·Neurochemistry International·Dennis J Selkoe
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Laszlo Lorand, Robert M Graham
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D J SelkoeY Ihara
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G A BerbersW W de Jong
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D RoyA Spector
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H NagarajV M Monnier
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Weraarchakul-BoonmarkL Lorand
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L LorandK N Parameswaran
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·A V Trejo-SkalliR D Goldman
Apr 15, 1992·European Journal of Biochemistry·P J GroenenW W de Jong
Nov 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P J RobinsonD S Harper
Oct 4, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hideo Nishigori
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·L Lorand
Feb 6, 2008·European Journal of Internal Medicine·Pål StenbergKlas Sjöberg
Jul 7, 2015·Biochimica Et Biophysica Acta·Amita MishraYogendra Sharma
Oct 28, 2011·Mass Spectrometry Reviews·Z Kyselova
Jul 15, 1985·Biochemical Pharmacology·A SenerW J Malaisse
Apr 15, 1991·Biochemical and Biophysical Research Communications·K FukudaJ F Chiu
Nov 27, 1985·Biochemical and Biophysical Research Communications·R J SiezenG B Benedek
Aug 15, 1987·Archives of Biochemistry and Biophysics·C W SlifeS W Snedeker
Sep 24, 2004·Experimental Eye Research·Mikhail LinetskyF Hu
Dec 1, 1990·Experimental Eye Research·A C Sen, B Chakrabarti
Jun 1, 1990·Experimental Eye Research·A Spector
May 1, 1987·Experimental Eye Research·G J BessemsH J Hoenders
Jan 1, 1985·Annals of the New York Academy of Sciences·D J SelkoeL K Duffy
Apr 29, 1988·Biochemical and Biophysical Research Communications·P T VelascoL Lorand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.