Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo

Journal of Virology
Shohreh ZareiVincent Piguet

Abstract

Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.

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Citations

Mar 22, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria Candela IglesiasPierre Charneau
Jan 1, 2011·Therapeutic Delivery·Anja Krause, Stefan Worgall
Jan 31, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Andrea AnnoniMaria Grazia Roncarolo
Jun 12, 2008·European Journal of Immunology·Javier Garcia CasadoFrédéric Lévy
Jan 5, 2011·Immunological Reviews·Biliang HuPin Wang
Apr 2, 2008·Expert Review of Vaccines·Yukai HeLouis D Falo
Mar 12, 2010·Expert Review of Vaccines·Mudita PinchaRenata Stripecke
Aug 14, 2009·Clinical and Vaccine Immunology : CVI·Akira TakagiToshitaka Akatsuka
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stacey L Sheasley-O'NeillVictor H Engelhard
May 9, 2007·The Journal of General Virology·Peter J HolstJan P Christensen
Jan 21, 2006·Cancer Research·Laurence ChapatteFrédéric Lévy

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