Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice

International Immunopharmacology
Haibo ChengFurong Li

Abstract

Fibrosis is one of the characteristic features of chronic kidney disease (CKD). Inflammatory reactions and oxidative stress are implicated in the pathogenesis of fibrosis of CKD. Leonurine (LEO) is one of the active compounds from Herba leonuri. In this study, we further evaluated its renoprotective effect in a mouse unilateral urethral obstruction (UUO), featuring the renal tubulointerstitial fibrosis and inflammation. In this model, pretreat of LEO before ureteral obstruction abolished the expression of fibronectin, suppressed the expression of α-SMA and type I/III collagen and down-regulated vimentin. LEO also modified the cytokine expression of TGF-β, TNF-α, IL-6 and IL-1β and suppressed the phosphorylation of Smad3. Moreover, LEO blocked phosphorylation of NF-κB, and inactivated the signaling pathways associated with the progression of kidney inflammatory response. Our data support that LEO is a candidate renoprotective compound for renal fibrosis through targeting the TGF-β/Smad3 and NF-κB pathway.

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Citations

Nov 28, 2015·International Journal of Molecular Sciences·Zhicheng LiuQin Zhou
Dec 24, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·You-You GuMing-Cai Qiu
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Dapeng Zhao, Zhongqiu Luan
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May 10, 2019·Chinese Journal of Integrative Medicine·Yun-Yun LiMei-Rong Du
May 24, 2019·BioMed Research International·Radu Claudiu FierascuCristina Elena Dinu-Pirvu
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Nov 26, 2020·Journal of Cardiovascular Pharmacology·Ruiyu WangJiadan Yang
Nov 8, 2019·Toxicology and Applied Pharmacology·Guangxu CaoBin Du
Jul 15, 2021·Acta Biochimica Et Biophysica Sinica·Yikong LinMeirong Du
Jul 29, 2021·Immunity, Inflammation and Disease·Fang Zong, Yingzi Zhao
Mar 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lin ChenYing-Yong Zhao

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