Leprosy and tuberculosis: the epidemiological consequences of cross-immunity

American Journal of Public Health
T LietmanS M Blower

Abstract

This study tested the hypothesis, first proposed by Chaussinand, that individual-level immunity acquired from exposure to tuberculosis may have contributed to the disappearance of leprosy from western Europe. The epidemiological consequences of cross-immunity were assessed by the formulation of a mathematical model of the transmission dynamics of tuberculosis and leprosy. The conditions under which Mycobacterium tuberculosis could have eradicated Mycobacterium leprae were derived in terms of the basic reproductive rates of the two infections and the degree of cross-immunity. If the degree of cross-immunity between two diseases within an individual is known, then the epidemiological consequences of this cross-immunity can be assessed with transmission modeling. The results of this analysis, in combination with previous estimates of the basic reproductive rate of tuberculosis and degree of cross-immunity, imply that tuberculosis could have contributed to the decline of leprosy if the basic reproductive rate of leprosy was low.

References

Jan 1, 1989·Journal of Mathematical Biology·H J Bremermann, H R Thieme
Aug 1, 1995·Nature Medicine·S M BlowerA R Moss
Sep 7, 1994·Journal of Theoretical Biology·R M May, M A Nowak
Nov 1, 1993·The Medical Clinics of North America·J H Bates, W W Stead
Mar 2, 1994·JAMA : the Journal of the American Medical Association·G A ColditzF Mosteller

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Citations

Mar 15, 2008·Inflammatory Bowel Diseases·Marcel A BehrOlivia Oxlade
Jul 2, 2010·EcoHealth·Jean-Paul GonzalezDominique Pontier
Jul 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T Lietman, S M Blower
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sally Blower, Li Ma
Aug 25, 2010·BMC Infectious Diseases·Lee R GibsonSusanna K Remold
Jul 7, 2007·Journal of Medical Case Reports·Chandrashekhar T SreeramareddyPv Kishore
Jan 12, 2011·Indian Journal of Dermatology, Venereology and Leprology·G Raghurama RaoUNKNOWN Shantisri
Dec 5, 2012·The American Journal of Tropical Medicine and Hygiene·Maria Ângela B TrindadeBernard Naafs
Aug 6, 2000·Tropical Medicine & International Health : TM & IH·J VisschedijkP Klatser
Jul 30, 2008·Microbes and Infection·Marcel A Behr
Nov 6, 2009·American Journal of Physical Anthropology·Anne C StoneCharlotte A Roberts
Oct 23, 2015·Parasites & Vectors·Cara E BrookTravis C Porco
Sep 12, 1998·Theoretical Population Biology·T C Porco, S M Blower
Nov 15, 2011·Medical Hypotheses·Ioannis D BassukasMax Hundeiker
Dec 19, 2012·Mathematical Biosciences·N Hohmann, A Voss-Böhme
Mar 6, 2012·Mathematical Biosciences·Cagri OzcaglarKristin P Bennett
Mar 24, 2015·PLoS Neglected Tropical Diseases·Violeta JimenezDanny Haddad
Aug 2, 2007·International Ophthalmology Clinics·Jenafir HouseTom M Lietman
Jun 19, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R M MayA R McLean
Mar 17, 2018·BMJ Case Reports·Seema ShettyPankaj Bahadur Nepali
Apr 2, 2015·Proceedings·Garrett L VickKatherine H Fiala
Sep 14, 2017·Computational and Mathematical Methods in Medicine·Lee Worden, Travis C Porco
Jun 4, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Graham F MedleyJan Hendrik Richardus
Mar 2, 2021·Clinical Genetics·Deng-Feng ZhangYong-Gang Yao
Oct 12, 2016·Microbiology Spectrum·Mark Spigelman, Mauro Rubini

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