Leprosy patients with lepromatous disease have an up-regulated IL-8 response that is unlinked to TNF-alpha responses

International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
Z HasanRabia Hussain

Abstract

Tumor necrosis factor (TNF-alpha) in conjunction with interferon-gamma (IFN-gamma) plays an important role in lymphocyte recruitment and granuloma formation in mycobacterial diseases. Lepromatous leprosy infections are typically associated with low to absent T cell responses and the absence of INF-gamma secretion. Chemokines such as IL-8, MCP-1, and MIP-1beta, have also been shown to recruit neutrophils and lymphocytes to the site of mycobacterial infections. We have studied IL-8 expression in relation to TNF-alpha and TGF-beta in monocytes from lepromatous patients (LL) as compared with healthy endemic controls. In endemic controls, no spontaneous expression of IL-8, TNF-alpha, and TGF-beta was observed, but BCG and M. leprae induced activation of all three cytokines. Lepromatous leprosy monocytes spontaneously expressed high levels of IL-8 and TGF-beta but negligible levels of TNF-alpha. A further increase in IL-8 secretion or gene expression by BCG or M. leprae was not significant. BCG, but not M. leprae, was able to stimulate TNF-alpha activation in lepromatous leprosy subjects. TGF-beta responses in LL were parallel to those of IL-8. This suggests a vigorous and active ongoing IL-8 response in lepromatous disease that is i...Continue Reading

Citations

Apr 21, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mahnaz TanveerRumina Hasan
Dec 26, 2008·BMC Infectious Diseases·Mahnaz TanveerRumina Hasan
Jan 1, 2008·Revista Da Sociedade Brasileira De Medicina Tropical·Vanessa Amaral MendonçaAntonio Lúcio Teixeira
Oct 12, 2018·Annals of Human Genetics·Julimary Suematsu AquinoJeane Eliete Laguila Visentainer
Oct 31, 2009·Acta Tropica·Vanessa Amaral MendonçaAntonio Lúcio Teixeira

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