PMID: 6983504Oct 1, 1982Paper

Leprosy. XII. T-cell subsets in lepromatous leprosy

International Journal of Dermatology
S D LimR M Fusaro

Abstract

The authors quantitated T-rosette-forming cell (TRFC) and T-cell subsets (T mu, T gamma) in the peripheral blood of twenty patients with lepromatous leprosy. The results obtained in their studies are as follows: (1) They reconfirmed the low levels of TRFC in patients with lepromatous type of leprosy; (2) T-cell subsets, both T mu (helper) and T gamma (suppressor) cells, showed lower levels in all patients with lepromatous leprosy than mean values of normal healthy controls; (3) The degree of decreased levels of T mu cells (96%) was more severe than other parameters TRFC (70%) and T gamma cells (47%) in all patients with lepromatous leprosy; and (4) It may be concluded that the alteration of the T-cell subset, T mu-cells, reflects a more fundamental abnormality than TRFC aberration in demonstrating the impairment of cell-mediated immunity in patients with lepromatous leprosy.

References

Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M AndreeffR A Good
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D M ParrottS Gupta
Jan 1, 1979·Immunological Reviews·L MorettaA Moretta
Sep 1, 1976·Clinical Immunology and Immunopathology·N I AbdouS Sadeghee
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari

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Citations

Dec 12, 2001·International Journal of Dermatology·J Abulafia, R A Vignale
Oct 14, 2017·PLoS Neglected Tropical Diseases·Edessa NegeraDiana N Lockwood
Mar 30, 2017·Frontiers in Immunology·Anastasia PolycarpouDiana N J Lockwood

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