Leptin--a regulator of islet function?: its plasma levels correlate with glucagon and insulin secretion in healthy women

Metabolism: Clinical and Experimental
B Ahrén, H Larsson

Abstract

It has previously been demonstrated that plasma leptin correlates to body fat content. It has also been demonstrated that in subjects with normal glucose tolerance, circulating leptin correlates to circulating insulin and to insulin secretion and that these relations are independent of body fat. However, whether leptin also covaries with other islet hormones is not known. We therefore studied the relation between plasma levels of leptin and glucagon secretion and circulating pancreatic polypeptide (PP) in healthy humans. Arginine was injected intravenously (5 g) at fasting and at 14 and 28 mmol/L, glucose in 71 postmenopausal women with normal glucose tolerance. In a multivariate analysis controlling for the influence of the body mass index, we found that circulating leptin correlated significantly to fasting insulin (r = .38, P = .002), and to circulating insulin at 14 mmol/L glucose levels (r = .29, P = .0019) and 28 mmol/L glucose (r = .32, P = .009), as well as to the insulin response to arginine at all three glucose levels (r > .30, P < .013). Circulating leptin, independently of the body mass index, also correlated to fasting glucagon (r = .31, P = .012) and to the glucagon response to arginine at all three glucose levels...Continue Reading

Citations

Aug 15, 2000·Annual Review of Nutrition·R B Harris
Feb 6, 2014·Acta Physiologica·T RomachoJ Eckel
Dec 19, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandro P DelitalaGiovanni M Pes
Feb 28, 2001·Diabetes, Obesity & Metabolism·H Larsson, B Ahrén
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Sep 20, 2012·The Journal of Endocrinology·Simon J Dunmore, James E P Brown
Dec 29, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B AhrénP J Havel
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